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Details on Person HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300...
| Class:Id | Summation:8878080 |
|---|---|
| _displayName | HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300... |
| _timestamp | 2022-12-29 17:09:14 |
| created | [InstanceEdit:8878082] Orlic-Milacic, Marija, 2016-06-29 |
| modified | [InstanceEdit:8939596] Orlic-Milacic, Marija, 2016-09-20 [InstanceEdit:8957313] Orlic-Milacic, Marija, 2017-01-24 [InstanceEdit:9822881] D'Eustachio, Peter, 2022-12-29 |
| text | HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300) histone acetyltransferase bound to the RUNX1:CBFB complex. RUNX1 is phosphorylated by HIPK2 at serine residues S249, S273, and S276. EP300 is phosphorylated by HIPK2 at multiple serine and threonine residues that have not been thoroughly identified. HIPK2-mediated phosphorylation contributed to the activation of histone acetyltransferase activity of EP300 at RUNX1 target promoters (Aikawa et al. 2006, Wee et al. 2008). |
| (summation) | [Reaction:8878050] HIPK2 phosphorylates RUNX1 and EP300 [Homo sapiens] |
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No pathways have been reviewed or authored by HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300... (8878080)
