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Details on Person HIPK2 phosphorylates RUNX1 and EP300

Class:Id	Reaction:8878050
_displayName	HIPK2 phosphorylates RUNX1 and EP300
_doRelease	TRUE
_timestamp	2017-05-09 14:03:52
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
catalystActivity	[CatalystActivity:8878065] protein serine/threonine kinase activity of HIPK2 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8878051] Orlic-Milacic, Marija, 2016-06-29
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input	[Complex:8878064] RUNX1:CBFB:EP300 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:8878057] PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis [LiteratureReference:8878049] Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation
modified	[InstanceEdit:8878070] Orlic-Milacic, Marija, 2016-06-29 [InstanceEdit:8878076] Orlic-Milacic, Marija, 2016-06-29 [InstanceEdit:8878083] Orlic-Milacic, Marija, 2016-06-29 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HIPK2 phosphorylates RUNX1 and EP300
output	[Complex:8878073] p-S249,S273,S276-RUNX1:CBFB:p-S,T-EP300 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:8878056] RUNX1:CBFB binds EP300 [Homo sapiens] [Reaction:8865320] CBFB binds RUNX1 [Homo sapiens]
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8921860] R-HSA-8878050.2
summation	[Summation:8878080] HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300...
(hasEvent)	[Pathway:8939243] RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9846635] Update Tracker - [Reaction:8878050] HIPK2 phosphorylates RUNX1 and EP300 - v84:[modifyText]
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