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Details on Person BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521

Class:Id	BlackBoxEvent:8877922
_displayName	BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521
_doRelease	TRUE
_timestamp	2017-08-10 19:56:48
authored	[InstanceEdit:8877920] Orlic-Milacic, Marija, 2016-06-28
compartment	[Compartment:7660] nucleoplasm [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:8877920] Orlic-Milacic, Marija, 2016-06-28
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
inferredFrom	[BlackBoxEvent:8937955] Bglap gene expression is negatively regulated by Yap1 [Rattus norvegicus] [BlackBoxEvent:8985025] Bglap gene expression is stimulated by the complex of Runx2 and Maf, or the complex of Runx2 and Wwtr1 (Taz) [Mus musculus] [BlackBoxEvent:9008164] Bglap gene expression is negatively regulated by Znf521 [Mus musculus]
input	[EntityWithAccessionedSequence:8877914] BGLAP gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8877901] Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA [LiteratureReference:8937826] Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription [LiteratureReference:8985000] Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation [LiteratureReference:8985222] TAZ, a transcriptional modulator of mesenchymal stem cell differentiation [LiteratureReference:8985461] The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation [LiteratureReference:9008133] Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity [LiteratureReference:9008879] Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms [LiteratureReference:9009204] Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor [LiteratureReference:9015269] Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene [LiteratureReference:9015233] Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation [LiteratureReference:9015275] Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication
modified	[InstanceEdit:8877931] Orlic-Milacic, Marija, 2016-06-28 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8937878] Orlic-Milacic, Marija, 2016-09-07 [InstanceEdit:8940503] Orlic-Milacic, Marija, 2016-09-26 [InstanceEdit:8941597] Orlic-Milacic, Marija, 2016-10-04 [InstanceEdit:8985029] Orlic-Milacic, Marija, 2017-04-11 [InstanceEdit:8985244] Orlic-Milacic, Marija, 2017-04-13 [InstanceEdit:8985496] Orlic-Milacic, Marija, 2017-04-17 [InstanceEdit:9008173] Orlic-Milacic, Marija, 2017-06-07 [InstanceEdit:9008886] Orlic-Milacic, Marija, 2017-06-13 [InstanceEdit:9009264] Orlic-Milacic, Marija, 2017-06-16 [InstanceEdit:9009648] Orlic-Milacic, Marija, 2017-06-21 [InstanceEdit:9009680] Orlic-Milacic, Marija, 2017-06-22 [InstanceEdit:9014260] Orlic-Milacic, Marija, 2017-07-27 [InstanceEdit:9015281] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015315] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015317] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015672] Orlic-Milacic, Marija, 2017-08-10 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521
output	[EntityWithAccessionedSequence:6807212] BGLAP(24-100) [endoplasmic reticulum lumen] [Homo sapiens]
precedingEvent	[Reaction:8877918] RUNX2:MAF complex binds the BGLAP gene promoter [Homo sapiens] [Reaction:8984994] RUNX2 binds MAF [Homo sapiens] [Reaction:9008877] RUNX2:CBFB binds BGLAP gene promoter [Homo sapiens] [Reaction:8865425] RUNX2 binds CBFB [Homo sapiens] [Reaction:9008412] CDK4 phosphorylates RUNX2 [Homo sapiens] [Reaction:9009208] Activated ERKs phosphorylate RUNX2 [Homo sapiens] [Reaction:8937869] RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter [Homo sapiens] [Reaction:8937864] RUNX2 binds tyrosine phosphorylated YAP1 [Homo sapiens] [Reaction:8985485] RUNX2 and RB1 bind the BGLAP gene promoter [Homo sapiens] [Reaction:8985460] RUNX2 binds RB1 [Homo sapiens] [Reaction:8985227] The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter [Homo sapiens] [Reaction:2064932] WWTR1 (TAZ) binds RUNX2 [Homo sapiens] [Reaction:9008137] RUNX2 binds ZNF521 and HDAC3 [Homo sapiens] [BlackBoxEvent:9007999] RUNX2 translocates to the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:8877923] Positive gene expression regulation by 'RUNX2:MAF:BGLAP gene [nucleoplasm]' [NegativeGeneExpressionRegulation:8937876] Negative gene expression regulation by 'RUNX2:CBFB:p-Y-YAP1:BGLAP gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8985240] Positive gene expression regulation by 'RUNX2:WWTR1:BGLAP gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8985498] Positive gene expression regulation by 'RUNX2:RB1:BGLAP gene [nucleoplasm]' [NegativeRegulation:9008166] Negative regulation by 'RUNX2:ZNF521:HDAC3 [nucleoplasm]' [PositiveGeneExpressionRegulation:9008887] Positive gene expression regulation by 'RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB):BGLAP gene [nucleoplasm]'
regulationReference	[RegulationReference:9641648] Negative gene expression regulation by 'RUNX2:CBFB:p-Y-YAP1:BGLAP gene [nucleoplasm]' Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription [RegulationReference:9641970] Positive gene expression regulation by 'RUNX2:RB1:BGLAP gene [nucleoplasm]' The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation [RegulationReference:9642446] Positive gene expression regulation by 'RUNX2:WWTR1:BGLAP gene [nucleoplasm]' TAZ, a transcriptional modulator of mesenchymal stem cell differentiation [RegulationReference:9642491] Positive gene expression regulation by 'RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB):BGLAP gene [nucleoplasm]' Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms [RegulationReference:9642659] Positive gene expression regulation by 'RUNX2:MAF:BGLAP gene [nucleoplasm]' Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA [RegulationReference:9642808] Negative regulation by 'RUNX2:ZNF521:HDAC3 [nucleoplasm]' Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity
releaseDate	2017-09-12
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8919996] R-HSA-8877922.4
summation	[Summation:8877929] Binding of RUNX2 to the OSE2 element in the promoter of the ...
(hasEvent)	[Pathway:8940973] RUNX2 regulates osteoblast differentiation [Homo sapiens]
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No pathways have been reviewed or authored by BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (8877922)