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Details on Person DENND5A,B exchange GTP for GDP on RAB39

Class:Id	Reaction:8877813
_displayName	DENND5A,B exchange GTP for GDP on RAB39
_doRelease	TRUE
_timestamp	2016-08-04 18:16:56
authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8877809] guanyl-nucleotide exchange factor activity of DENND5A,B [cytosol]
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:8877812] Rothfels, Karen, 2016-06-27
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
input	[SimpleEntity:29438] GTP [cytosol] [Complex:8877806] GGC-RAB39:GDP:GDIs,CHMs [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8877785] Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis [LiteratureReference:8877777] Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly [LiteratureReference:8849694] Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF) [LiteratureReference:6808983] The Golgi puppet master: COG complex at center stage of membrane trafficking interactions [LiteratureReference:6811200] Are Rab proteins the link between Golgi organization and membrane trafficking? [LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors
modified	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878004] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878060] Rothfels, Karen, 2016-06-29 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933457] Rothfels, Karen, 2016-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DENND5A,B exchange GTP for GDP on RAB39
output	[SimpleEntity:29420] GDP [cytosol] [DefinedSet:8875305] GDIs,CHMs [cytosol] [Homo sapiens] [Complex:8877804] GGC-RAB39:GTP [Golgi membrane] [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8906901] R-HSA-8877813.2
summation	[Summation:8877811] RAB39 proteins are involved in endolysosomal trafficking and...
(hasEvent)	[Pathway:8876198] RAB GEFs exchange GTP for GDP on RABs [Homo sapiens]
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No pathways have been reviewed or authored by DENND5A,B exchange GTP for GDP on RAB39 (8877813)