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Details on Person HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38

Class:Id	Reaction:8877760
_displayName	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38
_doRelease	TRUE
_timestamp	2017-05-26 15:29:06
authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8877747] guanyl-nucleotide exchange factor activity of HPS1:HPS4 [cytosol]
compartment	[Compartment:5668575] melanosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:8877759] Rothfels, Karen, 2016-06-27
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
input	[SimpleEntity:29438] GTP [cytosol] [Complex:8877756] RAB32,RAB38:GDP:GDIs,CHMs [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8877711] Mutation of melanosome protein RAB38 in chocolate mice [LiteratureReference:8877705] Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes [LiteratureReference:8877724] Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis [LiteratureReference:8877728] BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles [LiteratureReference:8877732] Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles [LiteratureReference:8877718] Varp interacts with Rab38 and functions as its potential effector [LiteratureReference:8877701] Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes [LiteratureReference:8877700] Structure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes [LiteratureReference:8876794] The Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytes [LiteratureReference:8877519] BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases
modified	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878004] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878060] Rothfels, Karen, 2016-06-29 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933460] Rothfels, Karen, 2016-08-04 [InstanceEdit:9007100] Jupe, Steve, 2017-05-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38
output	[SimpleEntity:29420] GDP [cytosol] [Complex:8877758] RAB32,RAB38:GTP [melanosome membrane] [Homo sapiens] [DefinedSet:8875305] GDIs,CHMs [cytosol] [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8928162] R-HSA-8877760.3
summation	[Summation:8877715] RAB32 and RAB38 play non-redundant but overlapping roles in ...
(hasEvent)	[Pathway:8876198] RAB GEFs exchange GTP for GDP on RABs [Homo sapiens]
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No pathways have been reviewed or authored by HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (8877760)