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Details on Person TRAPPC complexes exchange GTP for GDP on RAB1

Class:IdReaction:8877475
_displayNameTRAPPC complexes exchange GTP for GDP on RAB1
_doReleaseTRUE
_timestamp2016-08-04 18:17:06
authored[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity[CatalystActivity:8877457] guanyl-nucleotide exchange factor activity of TRAPPCs [cytosol]
compartment[Compartment:13946] transport vesicle membrane
[Compartment:70101] cytosol
created[InstanceEdit:8877474] Rothfels, Karen, 2016-06-22
edited[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
input[SimpleEntity:29438] GTP [cytosol]
[Complex:8877473] GGC-RAB1:GDP:GDIs,CHMs [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5688472] COPII and COPI traffic at the ER-Golgi interface
[LiteratureReference:8877434] Rab proteins of the endoplasmic reticulum: functions and interactors
[LiteratureReference:5685808] The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi
[LiteratureReference:8877462] Rab1 in cell signaling, cancer and other diseases
[LiteratureReference:5685801] TRAPPI tethers COPII vesicles by binding the coat subunit Sec23
[LiteratureReference:5685817] mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles
[LiteratureReference:5685780] Sequential interactions with Sec23 control the direction of vesicle traffic
[LiteratureReference:5685749] In sickness and in health: the role of TRAPP and associated proteins in disease
[LiteratureReference:8877429] The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes
[LiteratureReference:8877426] TRAPP stimulates guanine nucleotide exchange on Ypt1p
[LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases
[LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
[InstanceEdit:8878004] Rothfels, Karen, 2016-06-28
[InstanceEdit:8878060] Rothfels, Karen, 2016-06-29
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8933463] Rothfels, Karen, 2016-08-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTRAPPC complexes exchange GTP for GDP on RAB1
output[SimpleEntity:29420] GDP [cytosol]
[CandidateSet:8877468] GGC-RAB1:GTP [transport vesicle membrane] [Homo sapiens]
[DefinedSet:8875305] GDIs,CHMs [cytosol] [Homo sapiens]
releaseDate2016-09-19
reviewed[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8905515] R-HSA-8877475.2
summation[Summation:8877438] RAB1 is involved in COPII-mediated anterograde traffic from ...
(hasEvent)[Pathway:8876198] RAB GEFs exchange GTP for GDP on RABs [Homo sapiens]
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No pathways have been reviewed or authored by TRAPPC complexes exchange GTP for GDP on RAB1 (8877475)