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Details on Person TRAPPC complexes exchange GTP for GDP on RAB1
Class:Id Reaction:8877475
_displayName TRAPPC complexes exchange GTP for GDP on RAB1
_doRelease TRUE
_timestamp 2016-08-04 18:17:06
authored [InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity [CatalystActivity:8877457] guanyl-nucleotide exchange factor activity of TRAPPCs [cytosol]
compartment [Compartment:13946] transport vesicle membrane [Compartment:70101] cytosol
created [InstanceEdit:8877474] Rothfels, Karen, 2016-06-22
edited [InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
input [SimpleEntity:29438] GTP [cytosol] [Complex:8877473] GGC-RAB1:GDP:GDIs,CHMs [cytosol] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:5688472] COPII and COPI traffic at the ER-Golgi interface [LiteratureReference:8877434] Rab proteins of the endoplasmic reticulum: functions and interactors [LiteratureReference:5685808] The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi [LiteratureReference:8877462] Rab1 in cell signaling, cancer and other diseases [LiteratureReference:5685801] TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 [LiteratureReference:5685817] mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles [LiteratureReference:5685780] Sequential interactions with Sec23 control the direction of vesicle traffic [LiteratureReference:5685749] In sickness and in health: the role of TRAPP and associated proteins in disease [LiteratureReference:8877429] The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes [LiteratureReference:8877426] TRAPP stimulates guanine nucleotide exchange on Ypt1p [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified [InstanceEdit:8878001] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878004] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878060] Rothfels, Karen, 2016-06-29 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933463] Rothfels, Karen, 2016-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name TRAPPC complexes exchange GTP for GDP on RAB1
output [SimpleEntity:29420] GDP [cytosol] [CandidateSet:8877468] GGC-RAB1:GTP [transport vesicle membrane] [Homo sapiens] [DefinedSet:8875305] GDIs,CHMs [cytosol] [Homo sapiens]
releaseDate 2016-09-19
reviewed [InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:8905515] R-HSA-8877475.2
summation [Summation:8877438] RAB1 is involved in COPII-mediated anterograde traffic from ...
(hasEvent) [Pathway:8876198] RAB GEFs exchange GTP for GDP on RABs [Homo sapiens]
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