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Details on Person The RUNX1:CBFB complex in cooperation with NFATC2 (NFAT1) st...
| Class:Id | Summation:8877357 |
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| _displayName | The RUNX1:CBFB complex in cooperation with NFATC2 (NFAT1) st... |
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| _timestamp | 2017-01-24 21:04:23 |
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| created | [InstanceEdit:8877356] Orlic-Milacic, Marija, 2016-06-22 |
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| literatureReference | [LiteratureReference:8877190] Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 |
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| modified | [InstanceEdit:8877866] Orlic-Milacic, Marija, 2016-06-28
[InstanceEdit:8939639] Orlic-Milacic, Marija, 2016-09-20
[InstanceEdit:8941596] Orlic-Milacic, Marija, 2016-10-04
[InstanceEdit:8941608] Orlic-Milacic, Marija, 2016-10-05
[InstanceEdit:8957316] Orlic-Milacic, Marija, 2017-01-24 |
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| text | The RUNX1:CBFB complex in cooperation with NFATC2 (NFAT1) stimulates transcription of the IL2 gene. In the presence of FOXP3, however, transcription of the IL2 gene is suppressed. Suppressed IL2 production is one of the hallmarks of regulatory T cells (Tregs) (Wu et al. 2006, Ono et al. 2007). |
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| (summation) | [BlackBoxEvent:8877345] IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 [Homo sapiens] |
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