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Details on Person MADD exchanges GTP for GDP on RAB27

Class:Id	Reaction:8877308
_displayName	MADD exchanges GTP for GDP on RAB27
_doRelease	TRUE
_timestamp	2016-08-04 18:17:01
authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8877307] guanyl-nucleotide exchange factor activity of MADD [cytosol]
compartment	[Compartment:5668575] melanosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:8877306] Rothfels, Karen, 2016-06-21
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
input	[SimpleEntity:29438] GTP [cytosol] [Complex:8877298] GGC-RAB27:GDP:GDIs,CHMs [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8877196] Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets [LiteratureReference:8877242] Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes [LiteratureReference:8877240] Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding [LiteratureReference:8877230] Rab27 effectors, pleiotropic regulators in secretory pathways [LiteratureReference:8877246] Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans [LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors
modified	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878004] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878060] Rothfels, Karen, 2016-06-29 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933461] Rothfels, Karen, 2016-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MADD exchanges GTP for GDP on RAB27
output	[DefinedSet:8875305] GDIs,CHMs [cytosol] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol] [CandidateSet:8877303] RAB27:GTP [melanosome membrane] [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8912483] R-HSA-8877308.2
summation	[Summation:8877305] Vertebrate RAB27 exists in two isoforms, RAB27A and RAB27B, ...
(hasEvent)	[Pathway:8876198] RAB GEFs exchange GTP for GDP on RABs [Homo sapiens]
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No pathways have been reviewed or authored by MADD exchanges GTP for GDP on RAB27 (8877308)