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Details on Person The pathogenic bacteria Listeria monocytogenes can enter hos...
| Class:Id | Summation:8877047 |
|---|---|
| _displayName | The pathogenic bacteria Listeria monocytogenes can enter hos... |
| _timestamp | 2016-10-28 13:26:45 |
| created | [InstanceEdit:8877048] Orlic-Milacic, Marija, 2016-06-17 |
| modified | [InstanceEdit:8877050] Orlic-Milacic, Marija, 2016-06-17 [InstanceEdit:8877051] Orlic-Milacic, Marija, 2016-06-17 [InstanceEdit:8877119] Orlic-Milacic, Marija, 2016-06-20 [InstanceEdit:8943576] Orlic-Milacic, Marija, 2016-10-26 [InstanceEdit:8943674] Orlic-Milacic, Marija, 2016-10-28 |
| text | The pathogenic bacteria Listeria monocytogenes can enter host cells through endocytosis triggered by binding of the bacterial cell wall protein internalin (InlA) to the E-cadherin (CDH1) complex at the host cell plasma membrane (Mengaud et al. 1996, Lecuit et al. 1999). Binding of InlA to CDH1, similar to CDH1 engagement during normal cell-to-cell adhesion, triggers activation of the SRC protein tyrosine kinase and phosphorylation of CDH1 and CDH1-bound beta-catenin (CTNNB1) (Fujita et al. 2002, McLachlan et al. 2007, Sousa et al. 2007, Bonazzi et al. 2008). Integrins likely contribute to CDH1-triggered SRC activation, and ERKs (MAPK1 and MAPK3), ROCKs and MLCK may also be involved (Avizienyte et al. 2002, Avizienyte et al. 2004, Martinez-Rico et al. 2010). FAK1 (PTK2), a SRC-regulated protein tyrosine kinase, may contribute to SRC-mediated regulation of CDH1 (Avizienyte et al. 2002). Phosphorylation of CDH1 and CTNNB1 by SRC creates docking sites for a CBL-like ubiquitin protein ligase Hakai (CBLL1). CBLL1 ubiquitinates SRC-phosphorylated CDH1 and CTNNB1 upon InlA binding, as well as in the context of CDH1-mediated cell-to-cell adhesion, thus triggering CDH1 endocytosis (Fujita et al. 2002, Bonazzi et al. 2008, Mukherjee et al. 2012). CBLL1 may also undergo SRC-mediated phosphorylation and subsequent autoubiquitination (Fujita et al. 2002). Both clathrin-mediated and caveolin-mediated endocytosis are implicated in the InlA-mediated entry of Listeria monocytogenes to host cells (Veiga et al. 2007). SRC-mediated phosphorylation of cortactin and the ARP2/3 complex involved in actin polymerization is implicated in CDH1 endocytosis and Listeria monocytogenes internalization (Sousa et al. 2007, Ren et al. 2009). |
| (summation) | [Pathway:8876493] InlA-mediated entry of Listeria monocytogenes into host cells [Homo sapiens] |
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