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Query author contributions in Reactome

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Details on Person CBL-like E3 ubiquitin ligase Hakai (CBLL1) ubiquitinates the...

Class:IdSummation:8877016
_displayNameCBL-like E3 ubiquitin ligase Hakai (CBLL1) ubiquitinates the...
_timestamp2016-10-28 13:26:44
created[InstanceEdit:8877015] Orlic-Milacic, Marija, 2016-06-17
literatureReference[LiteratureReference:8876930] Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
[LiteratureReference:8876973] Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes
modified[InstanceEdit:8877051] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8877123] Orlic-Milacic, Marija, 2016-06-20
[InstanceEdit:8943674] Orlic-Milacic, Marija, 2016-10-28
textCBL-like E3 ubiquitin ligase Hakai (CBLL1) ubiquitinates the E-cadherin complex engaged by binding of E-cadherin (CDH1) to internalin (InlA), a cell wall protein of Listeria monocytogenes. CBLL1 ubiquitinates both CDH1 and CDH1-bound beta-catenin (CTNNB1), triggering endocytosis of the InlA-bound CDH1 complex and entry of bacteria to host cells. It appears that both clathrin-mediated and caveolin-mediated endocytosis contribute to invasion of host cells by Listeria monocytogenes via the InlA-CDH1 route (Bonazzi et al. 2008).
CBLL1 may undergo SRC-mediated phosphorylation and subsequent auto-ubiquitination (Fujita et al. 2002).
(summation)[Reaction:8877003] CBLL1 ubiqutinates the InlA-bound CDH1 complex [Homo sapiens]
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No pathways have been reviewed or authored by CBL-like E3 ubiquitin ligase Hakai (CBLL1) ubiquitinates the... (8877016)
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