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Details on Person CBLL1 ubiqutinates the InlA-bound CDH1 complex

Class:IdReaction:8877003
_displayNameCBLL1 ubiqutinates the InlA-bound CDH1 complex
_doReleaseTRUE
_timestamp2026-03-26 14:17:05
authored[InstanceEdit:8876400] Orlic-Milacic, Marija, 2016-06-14
catalystActivity[CatalystActivity:8877005] ubiquitin protein ligase activity of InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:25413] Gram-positive-bacterium-type cell wall
created[InstanceEdit:8877004] Orlic-Milacic, Marija, 2016-06-17
disease[Disease:8875363] listeriosis
edited[InstanceEdit:8943577] Orlic-Milacic, Marija, 2016-10-26
entityOnOtherCell[EntityWithAccessionedSequence:8876505] InlA [Gram-positive-bacterium-type cell wall] [Listeria monocytogenes]
input[Complex:8876983] InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8876973] Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes
modified[InstanceEdit:8877014] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8877017] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8877121] Orlic-Milacic, Marija, 2016-06-20
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8933575] Orlic-Milacic, Marija, 2016-08-08
[InstanceEdit:8943566] Orlic-Milacic, Marija, 2016-10-26
[InstanceEdit:8943578] Orlic-Milacic, Marija, 2016-10-26
[InstanceEdit:8948175] Orlic-Milacic, Marija, 2016-11-11
[InstanceEdit:9634773] Rothfels, Karen, 2019-01-15
[InstanceEdit:9638137] Orlic-Milacic, Marija, 2019-02-25
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9836317] D'Eustachio, Peter, 2023-05-25
[InstanceEdit:9985750] D'Eustachio, Peter, 2026-03-26
nameCBLL1 ubiqutinates the InlA-bound CDH1 complex
Hakai ubiqutinates InlA-bound E-cadherin complex
output[Complex:8877010] InlA:Ub-K,p-Y753,Y754-CDH1:Ub-K,p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane] [Homo sapiens]
precedingEvent
relatedSpecies[Species:8875362] Listeria monocytogenes
releaseDate2016-12-12
reviewed[InstanceEdit:8943564] Schwerk, Christian, 2016-10-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8911546] R-HSA-8877003.4
summation[Summation:8877016] CBL-like E3 ubiquitin ligase Hakai (CBLL1) ubiquitinates the...
(hasEvent)[Pathway:8876493] InlA-mediated entry of Listeria monocytogenes into host cells [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778385] Update Tracker - [Reaction:8877003] CBLL1 ubiqutinates the InlA-bound CDH1 complex - v68:[add_removeInput]
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