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Details on Person CBLL1 binds SRC-phosphorylated CDH1 complex

Class:Id	Reaction:8876993
_displayName	CBLL1 binds SRC-phosphorylated CDH1 complex
_doRelease	TRUE
_timestamp	2026-03-26 14:17:03
authored	[InstanceEdit:8876400] Orlic-Milacic, Marija, 2016-06-14
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:25413] Gram-positive-bacterium-type cell wall
created	[InstanceEdit:8876977] Orlic-Milacic, Marija, 2016-06-17
disease	[Disease:8875363] listeriosis
edited	[InstanceEdit:8943577] Orlic-Milacic, Marija, 2016-10-26
entityOnOtherCell	[EntityWithAccessionedSequence:8876505] InlA [Gram-positive-bacterium-type cell wall] [Listeria monocytogenes]
input	[Complex:8876941] InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CTNND1 [plasma membrane] [Homo sapiens] [Complex:8876991] CBLL1 dimer:Zn2+ [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8876973] Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes
modified	[InstanceEdit:8876998] Orlic-Milacic, Marija, 2016-06-17 [InstanceEdit:8877001] Orlic-Milacic, Marija, 2016-06-17 [InstanceEdit:8877852] Orlic-Milacic, Marija, 2016-06-28 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933575] Orlic-Milacic, Marija, 2016-08-08 [InstanceEdit:8943566] Orlic-Milacic, Marija, 2016-10-26 [InstanceEdit:8943578] Orlic-Milacic, Marija, 2016-10-26 [InstanceEdit:8948175] Orlic-Milacic, Marija, 2016-11-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9836317] D'Eustachio, Peter, 2023-05-25 [InstanceEdit:9985750] D'Eustachio, Peter, 2026-03-26
name	CBLL1 binds SRC-phosphorylated CDH1 complex Hakai binds SRC-phosphorylated E-cadherin complex
output	[Complex:8876983] InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:418996] CTNND1 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8876948] SRC phosphorylates InlA-bound CDH1 and CTNNB1 [Homo sapiens] [BlackBoxEvent:112333] SRC autophosphorylation is positively regulated by InlA-bound CDH1 [Homo sapiens]
relatedSpecies	[Species:8875362] Listeria monocytogenes
releaseDate	2016-12-12
reviewed	[InstanceEdit:8943564] Schwerk, Christian, 2016-10-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8893370] R-HSA-8876993.3
summation	[Summation:8876997] CBL-like E3 ubiquitin ligase Hakai (CBLL1) binds to SRC-phos...
(hasEvent)	[Pathway:8876493] InlA-mediated entry of Listeria monocytogenes into host cells [Homo sapiens]
(precedingEvent)	[Reaction:8877003] CBLL1 ubiqutinates the InlA-bound CDH1 complex [Homo sapiens]
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No pathways have been reviewed or authored by CBLL1 binds SRC-phosphorylated CDH1 complex (8876993)