Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person SRC-mediated phosphorylation of E-cadherin (CDH1) is needed ...

Class:IdSummation:8876970
_displayNameSRC-mediated phosphorylation of E-cadherin (CDH1) is needed ...
_timestamp2016-06-28 14:39:08
created[InstanceEdit:8876969] Orlic-Milacic, Marija, 2016-06-17
literatureReference[LiteratureReference:8876973] Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes
[LiteratureReference:8876930] Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
[LiteratureReference:8876990] Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin
modified[InstanceEdit:8876974] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8876995] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8877849] Orlic-Milacic, Marija, 2016-06-28
textSRC-mediated phosphorylation of E-cadherin (CDH1) is needed for InlA-mediated entry of Listeria monocytogenes into host cells (Bonazzi et al. 2008). At cell adhesion sites, SRC is known to phosphorylate CDH1 at tyrosine residues Y753 and Y754 and CDH1-bound beta-catenin (CTNNB1) at an unknown tyrosine residue. SRC-phosphorylated tyrosines of CDH1 and CTNNB1 serve as docking sites for the E3 ubiquitin ligase Hakai (CBLL1) (Fujita et al. 2002, Mukherjee et al. 2012).
(summation)[BlackBoxEvent:8876948] SRC phosphorylates InlA-bound CDH1 and CTNNB1 [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by SRC-mediated phosphorylation of E-cadherin (CDH1) is needed ... (8876970)
Follow Reactome