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Details on Person SRC activation involves autophosphorylation at tyrosine resi...

Class:Id	Summation:8876950
_displayName	SRC activation involves autophosphorylation at tyrosine resi...
_timestamp	2016-06-17 17:16:50
created	[InstanceEdit:8876954] Orlic-Milacic, Marija, 2016-06-17
literatureReference	[LiteratureReference:8876930] Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex [LiteratureReference:112334] Regulation, substrates and functions of src. [LiteratureReference:8876932] Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cells [LiteratureReference:8876960] E-cadherin adhesion activates c-Src signaling at cell-cell contacts [LiteratureReference:8876964] Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling [LiteratureReference:8876956] Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility
text	SRC activation involves autophosphorylation at tyrosine residue Y419 (Brown and Cooper 1996). Binding of the Listeria monocytogenes cell wall protein InlA to E-cadherin (CDH1) triggers SRC autophosphorylation at Y419 through an unknown mechanism (Sousa et al. 2007). CDH1 engagement (adhesion) at cell-cell contacts is also known to induce SRC autophosphorylation (Fujita et al. 2002, McLachlan et al. 2007) and may involve integrins (Avizienyte et al. 2002, Martinez-Rico et al. 2010), but the process has not been fully elucidated.
(summation)	[BlackBoxEvent:112333] SRC autophosphorylation is positively regulated by InlA-bound CDH1 [Homo sapiens]
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