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Details on Person Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA

Class:Id	Reaction:8876889
_displayName	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA
_doRelease	TRUE
_timestamp	2024-08-02 17:56:51
authored	[InstanceEdit:8876886] Jassal, Bijay, 2016-06-17
catalystActivity	[CatalystActivity:8876888] acetyl-CoA carboxylase activity of Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:8876890] Jassal, Bijay, 2016-06-17
crossReference	[DatabaseIdentifier:9911371] RHEA:11309
edited	[InstanceEdit:8876886] Jassal, Bijay, 2016-06-17
goBiologicalProcess	[GO_BiologicalProcess:260763] fatty acid homeostasis
input	[SimpleEntity:76183] Ac-CoA [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:111627] HCO3- [cytosol]
internalReviewed	[InstanceEdit:9911507] D'Eustachio, Peter, 2024-05-31
literatureReference	[LiteratureReference:200019] Expression, purification, and characterization of human acetyl-CoA carboxylase 2 [LiteratureReference:201319] The subcellular localization of acetyl-CoA carboxylase 2 [LiteratureReference:8866943] Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis [LiteratureReference:3323162] Selectivity in post-translational biotin addition to five human carboxylases [LiteratureReference:8866948] Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate [LiteratureReference:8867331] Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl-CoA carboxylase 2 [LiteratureReference:8866946] Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis
modified	[InstanceEdit:8878976] Jassal, Bijay, 2016-07-14 [InstanceEdit:8878977] Jassal, Bijay, 2016-07-14 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8936338] Jassal, Bijay, 2016-08-18 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29 [InstanceEdit:9911506] D'Eustachio, Peter, 2024-05-31 [InstanceEdit:9917363] D'Eustachio, Peter, 2024-08-02
name	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:75848] ACLY tetramer transforms CIT to Ac-CoA [Homo sapiens] [Reaction:75849] SLC25A1 exchanges CIT and MAL [Homo sapiens] [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX [Homo sapiens] [BlackBoxEvent:9856605] Transcriptional activation of ACACB by ChREBP:MLX [Homo sapiens] [Reaction:9856548] MLXIPL:MLX binds ACACB gene promoter [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:8876897] Positive regulation by 'CIT [cytosol]' [PositiveRegulation:8878972] Positive regulation by 'MID1IP1:THRSP [cytosol]'
regulationReference	[RegulationReference:9641816] Positive regulation by 'MID1IP1:THRSP [cytosol]' Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate
releaseDate	2016-09-19
reviewed	[InstanceEdit:8934767] D'Eustachio, Peter, 2016-08-12 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8889757] R-HSA-8876889.5
structureModified	[InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29
summation	[Summation:8876894] Mitochondrial acetyl-CoA carboxylase 2 (ACACB, ACC2) (Kim et...
(hasEvent)	[Pathway:200425] Carnitine shuttle [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9846805] Update Tracker - [Reaction:8876889] Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA - v84:[modifyText] [_UpdateTracker:9919349] Update Tracker - [Reaction:8876889] Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA - v90:[removeOutput]
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