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Details on Person DENND6A,B exchange GTP for GDP on RAB14

Class:Id	Reaction:8876616
_displayName	DENND6A,B exchange GTP for GDP on RAB14
_doRelease	TRUE
_timestamp	2016-08-04 18:16:57
authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8876612] guanyl-nucleotide exchange factor activity of DENND6A,B [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:262783] recycling endosome membrane
created	[InstanceEdit:8876613] Rothfels, Karen, 2016-06-15
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
input	[SimpleEntity:29438] GTP [cytosol] [Complex:8876596] GGC-RAB14:GDP:GDIs,CHMs [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8876664] Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes [LiteratureReference:8876633] A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes [LiteratureReference:8876662] Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells [LiteratureReference:8876675] Rab14 regulation of claudin-2 trafficking modulates epithelial permeability and lumen morphogenesis [LiteratureReference:3827964] ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation [LiteratureReference:8876634] ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling [LiteratureReference:8876639] ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles [LiteratureReference:8876657] Junctional adhesion molecule-C is a soluble mediator of angiogenesis [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified	[InstanceEdit:8876679] Rothfels, Karen, 2016-06-15 [InstanceEdit:8878001] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878004] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878060] Rothfels, Karen, 2016-06-29 [InstanceEdit:8878086] Rothfels, Karen, 2016-06-29 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933458] Rothfels, Karen, 2016-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DENND6A,B exchange GTP for GDP on RAB14
output	[DefinedSet:8875305] GDIs,CHMs [cytosol] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol] [Complex:8876595] GGC-RAB14:GTP [recycling endosome membrane] [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8883289] R-HSA-8876616.2
summation	[Summation:8876659] RAB14 is involved in the trafficking of GLUT4 to the plasma ...
(hasEvent)	[Pathway:8876198] RAB GEFs exchange GTP for GDP on RABs [Homo sapiens]
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No pathways have been reviewed or authored by DENND6A,B exchange GTP for GDP on RAB14 (8876616)