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Details on Person RAB13 GEFs exchange GTP for GDP on RAB13

Class:Id	Reaction:8876615
_displayName	RAB13 GEFs exchange GTP for GDP on RAB13
_doRelease	TRUE
_timestamp	2016-08-04 18:17:05
authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8876610] guanyl-nucleotide exchange factor activity of RAB13 GEFs [cytosol]
compartment	[Compartment:204883] cell junction [Compartment:70101] cytosol
created	[InstanceEdit:8876613] Rothfels, Karen, 2016-06-15
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
input	[SimpleEntity:29438] GTP [cytosol] [Complex:8876604] GGC-RAB13:GDP:GDIs,CHMs [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8876526] The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells [LiteratureReference:8876545] Rab13 regulates PKA signaling during tight junction assembly [LiteratureReference:8876546] Rab13 mediates the continuous endocytic recycling of occludin to the cell surface [LiteratureReference:8876565] JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin [LiteratureReference:8876529] The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions [LiteratureReference:8876541] Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells [LiteratureReference:1449646] Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells [LiteratureReference:8876536] Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2 [LiteratureReference:8876556] Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking [LiteratureReference:8876583] A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis [LiteratureReference:8876517] Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures [LiteratureReference:8876578] Bioinformatics analysis reveals disturbance mechanism of MAPK signaling pathway and cell cycle in Glioblastoma multiforme [LiteratureReference:8876570] DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior [LiteratureReference:8876534] Regulation of Cancer Cell Behavior by the Small GTPase Rab13 [LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors [LiteratureReference:8876575] Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878004] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878060] Rothfels, Karen, 2016-06-29 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933463] Rothfels, Karen, 2016-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAB13 GEFs exchange GTP for GDP on RAB13
output	[DefinedSet:8875305] GDIs,CHMs [cytosol] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol] [Complex:8876599] GGC-RAB13:GTP [cell junction] [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8883073] R-HSA-8876615.2
summation	[Summation:8876614] RAB13 is involved in the trafficking of proteins in the bios...
(hasEvent)	[Pathway:8876198] RAB GEFs exchange GTP for GDP on RABs [Homo sapiens]
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