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Details on Person p-ULK1 phosphorylates DENND3

Class:Id	Reaction:8876446
_displayName	p-ULK1 phosphorylates DENND3
_doRelease	TRUE
_timestamp	2016-08-08 17:40:10
authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8876445] protein serine/threonine kinase activity of p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8876444] Rothfels, Karen, 2016-06-14
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
input	[EntityWithAccessionedSequence:8876435] DENND3 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5672133] The ULK1 complex: sensing nutrient signals for autophagy activation [LiteratureReference:8876411] Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4 [LiteratureReference:8876402] Dennd3 functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts [LiteratureReference:8876410] Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy [LiteratureReference:8876418] PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer [LiteratureReference:8876427] Small GTPase Rab12 regulates constitutive degradation of transferrin receptor [LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors [LiteratureReference:8876569] Endocytosis and autophagy: Shared machinery for degradation [LiteratureReference:8876440] DENND3: a signaling/trafficking interface in autophagy
modified	[InstanceEdit:8876621] Rothfels, Karen, 2016-06-15 [InstanceEdit:8878004] Rothfels, Karen, 2016-06-28 [InstanceEdit:8878060] Rothfels, Karen, 2016-06-29 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933463] Rothfels, Karen, 2016-08-04 [InstanceEdit:8933626] Rothfels, Karen, 2016-08-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-ULK1 phosphorylates DENND3
output	[EntityWithAccessionedSequence:8876434] p-S472,S490-DENND3 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:5672008] Thr-180 of ULK1 is phosphorylated [Homo sapiens] [Reaction:5665868] AMPK (complex) phosphorylates ULK1 (complex) [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8893915] R-HSA-8876446.2
summation	[Summation:8876430] ULK1 is a serine-threonine kinase with key roles in macroaut...
(hasEvent)	[Pathway:8876198] RAB GEFs exchange GTP for GDP on RABs [Homo sapiens]
(precedingEvent)	[Reaction:8876454] DENND3 exchanges GTP for GDP on RAB12 [Homo sapiens]
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