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Details on Person SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol

Class:Id	Reaction:8876312
_displayName	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-08-13 18:09:56
authored	[InstanceEdit:8876306] Jassal, Bijay, 2016-06-13
catalystActivity	[CatalystActivity:8876300] organic acid:sodium symporter activity of SLC5A12 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8876306] Jassal, Bijay, 2016-06-13
crossReference	[DatabaseIdentifier:9958943] RHEA:75792 [DatabaseIdentifier:9958944] RHEA:75796 [DatabaseIdentifier:9958942] RHEA:75800
edited	[InstanceEdit:8876306] Jassal, Bijay, 2016-06-13
input	[DefinedSet:8876310] LACT, PYR, NCA [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:8876303] Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney
modified	[InstanceEdit:8876313] Jassal, Bijay, 2016-06-13 [InstanceEdit:8877171] Jassal, Bijay, 2016-06-21 [InstanceEdit:8878409] Jassal, Bijay, 2016-07-04 [InstanceEdit:8879142] Jassal, Bijay, 2016-07-15 [InstanceEdit:8879143] Jassal, Bijay, 2016-07-15 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8932134] Jassal, Bijay, 2016-07-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9958945] Stephan, Ralf, 2025-06-26 [InstanceEdit:9963193] Stephan, Ralf, 2025-08-13
name	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol
output	[DefinedSet:8876304] LACT, PYR, NCA [cytosol] [SimpleEntity:83910] Na+ [cytosol]
precedingEvent	[Reaction:373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region [Homo sapiens] [Reaction:71849] LDH tetramer reduces PYR to LACT [Homo sapiens] [Reaction:8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol [Homo sapiens] [Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT [Homo sapiens] [Reaction:373867] BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol [Homo sapiens] [Reaction:429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8879141] D'Eustachio, Peter, 2016-07-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8881945] R-HSA-8876312.3
summation	[Summation:8876302] The sodium-coupled monocarboxylate transporter 2 (SLC5A12, S...
(hasEvent)	[Pathway:428643] Organic anion transport by SLC5/17/25 transporters [Homo sapiens]
(precedingEvent)	[Reaction:373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region [Homo sapiens] [Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT [Homo sapiens]
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