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Details on Person SLC25A18,22 import L-Glu, H+

Class:Id	Reaction:8875623
_displayName	SLC25A18,22 import L-Glu, H+
_doRelease	TRUE
_timestamp	2024-01-07 08:21:43
authored	[InstanceEdit:8875617] Jassal, Bijay, 2016-06-08
catalystActivity	[CatalystActivity:8875618] amino acid:proton symporter activity of SLC25A18,A22 [mitochondrial inner membrane]
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:8875617] Jassal, Bijay, 2016-06-08
crossReference	[DatabaseIdentifier:9856911] RHEA:70957
edited	[InstanceEdit:8875617] Jassal, Bijay, 2016-06-08
input	[SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9857487] D'Eustachio, Peter, 2024-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:8875620] Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms [LiteratureReference:8875837] Impaired mitochondrial glutamate transport in autosomal recessive neonatal myoclonic epilepsy [LiteratureReference:9857035] Neonatal Seizures: An Overview of Genetic Causes and Treatment Options
modified	[InstanceEdit:8875834] Jassal, Bijay, 2016-06-09 [InstanceEdit:8875863] Jassal, Bijay, 2016-06-09 [InstanceEdit:8878163] Jassal, Bijay, 2016-06-30 [InstanceEdit:8878381] Jassal, Bijay, 2016-07-04 [InstanceEdit:8879142] Jassal, Bijay, 2016-07-15 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8932134] Jassal, Bijay, 2016-07-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856910] Stephan, Ralf, 2023-12-28 [InstanceEdit:9857034] Stephan, Ralf, 2023-12-30 [InstanceEdit:9857486] Stephan, Ralf, 2024-01-07
name	SLC25A18,22 import L-Glu, H+ SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix
output	[SimpleEntity:113552] L-Glu [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Homo sapiens] [Reaction:372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] [Homo sapiens] [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens] [Reaction:372448] SLC25A12,13 exchange L-Glu and L-Asp [Homo sapiens] [Reaction:5691507] ASPA deacetylates NAASP to acetate and L-aspartate [Homo sapiens] [Reaction:6797627] ASPG hydrolyses L-Asn to L-Asp [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8879141] D'Eustachio, Peter, 2016-07-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8926765] R-HSA-8875623.3
summation	[Summation:8875619] Mitochondrial glutamate carriers 1 and 2 (SLC25A22, GC1, and...
(hasEvent)	[Pathway:442660] SLC-mediated transport of neurotransmitters [Homo sapiens] [Pathway:9856872] Malate-aspartate shuttle [Homo sapiens]
(precedingEvent)	[Reaction:70613] GOT2 transaminates OA and L-Glu [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9863969] Update Tracker - [Reaction:8875623] SLC25A18,22 import L-Glu, H+ - v88:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by SLC25A18,22 import L-Glu, H+ (8875623)