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Details on Person DOCK7, recruited to the activated MET receptor complex throu...
| Class:Id | Summation:8875593 |
|---|---|
| _displayName | DOCK7, recruited to the activated MET receptor complex throu... |
| _timestamp | 2016-06-08 18:20:04 |
| created | [InstanceEdit:8875594] Orlic-Milacic, Marija, 2016-06-07 |
| literatureReference | [LiteratureReference:8875583] Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation [LiteratureReference:8875758] Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration |
| modified | [InstanceEdit:8875761] Orlic-Milacic, Marija, 2016-06-08 |
| text | DOCK7, recruited to the activated MET receptor complex through GAB1 and, possibly, CRK or CRKL, stimulates guanyl nucleotide exchange on RAC1 from GDP to GTP, resulting in RAC1 activation and HGF-stimulated cell migration/invasion (Murray et al. 2014). Activation of RAC1 in response to HGF stimulation was reported to depend on the endosomal protein RAB5 and RAC1 guanyl exchange factor (GEF) TIAM1 (Palamidessi et al. 2008). |
| (summation) | [BlackBoxEvent:8875591] DOCK7 activates RAC1 [Homo sapiens] |
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No pathways have been reviewed or authored by DOCK7, recruited to the activated MET receptor complex throu... (8875593)
