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Details on Person Recruitment of CRK or related CRKL to MET-phosphorylated GAB...

Class:IdSummation:8875587
_displayNameRecruitment of CRK or related CRKL to MET-phosphorylated GAB...
_timestamp2016-06-13 17:24:57
created[InstanceEdit:8875577] Orlic-Milacic, Marija, 2016-06-07
modified[InstanceEdit:8875638] Orlic-Milacic, Marija, 2016-06-08
[InstanceEdit:8876343] Orlic-Milacic, Marija, 2016-06-13
textRecruitment of CRK or related CRKL to MET-phosphorylated GAB1 results in increased level of activated RAC1 (RAC1:GTP), a necessary step in HGF-induced cell motility (Lamorte et al. 2002, Watanabe et al. 2006). DOCK7 was recently implicated as a RAC1 guanyl nucleotide exchange factor (GEF) recruited to activated MET receptor via GAB1. Binding of DOCK7 to GAB1-bound CRK or CRKL was proposed but has not been examined (Murray et al. 2014).
(summation)[BlackBoxEvent:8875576] CRK,CRKL recruits RAC1 GEF to activated MET [Homo sapiens]
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