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Details on Person CRK,CRKL recruits RAC1 GEF to activated MET

Class:Id	BlackBoxEvent:8875576
_displayName	CRK,CRKL recruits RAC1 GEF to activated MET
_doRelease	TRUE
_timestamp	2016-07-19 17:47:21
authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8875577] Orlic-Milacic, Marija, 2016-06-07
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
input	[Complex:8875548] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] [Homo sapiens] [CandidateSet:8875579] (DOCK7) [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8875583] Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation [LiteratureReference:8875559] Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions [LiteratureReference:8875637] Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines
modified	[InstanceEdit:8875638] Orlic-Milacic, Marija, 2016-06-08 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8931694] Orlic-Milacic, Marija, 2016-07-18 [InstanceEdit:8931945] Orlic-Milacic, Marija, 2016-07-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CRK,CRKL recruits RAC1 GEF to activated MET
output	[Complex:8875574] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8875540] GAB1 recruits CRK,CRKL to MET [Homo sapiens] [Reaction:8851933] MET phosphorylates GAB1 [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8892117] R-HSA-8875576.2
summation	[Summation:8875587] Recruitment of CRK or related CRKL to MET-phosphorylated GAB...
(hasEvent)	[Pathway:8875555] MET activates RAP1 and RAC1 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8875591] DOCK7 activates RAC1 [Homo sapiens]
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No pathways have been reviewed or authored by CRK,CRKL recruits RAC1 GEF to activated MET (8875576)