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Query author contributions in Reactome

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Details on Person GAB1 recruits CRK,CRKL to MET

Class:IdReaction:8875540
_displayNameGAB1 recruits CRK,CRKL to MET
_doReleaseTRUE
_timestamp2017-11-22 02:17:14
authored[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:8875539] Orlic-Milacic, Marija, 2016-06-07
edited[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
input[DefinedSet:8851943] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] [Homo sapiens]
[DefinedSet:381945] CRK, CRKL [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8875541] Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL
[LiteratureReference:8875550] Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program
[LiteratureReference:8875549] A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein
[LiteratureReference:8875547] Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation
[LiteratureReference:8851912] Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
modified[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8931694] Orlic-Milacic, Marija, 2016-07-18
[InstanceEdit:8931945] Orlic-Milacic, Marija, 2016-07-19
[InstanceEdit:9029732] Orlic-Milacic, Marija, 2017-11-22
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameGAB1 recruits CRK,CRKL to MET
output[Complex:8875548] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2016-09-19
reviewed[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11
[InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8892848] R-HSA-8875540.3
summation[Summation:8875554] Splicing isoforms of adapter protein CRK, CRK-1 (CRKI) and C...
(hasEvent)[Pathway:8875555] MET activates RAP1 and RAC1 [Homo sapiens]
(precedingEvent)[Reaction:8875558] RAPGEF1 binds CRK,CRKL [Homo sapiens]
[BlackBoxEvent:8875576] CRK,CRKL recruits RAC1 GEF to activated MET [Homo sapiens]
[BlackBoxEvent:8875661] GGA3 associates with activated MET receptor [Homo sapiens]
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No pathways have been reviewed or authored by GAB1 recruits CRK,CRKL to MET (8875540)
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