Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person CBL recruits the complex of SH3KBP1 (CIN85) and endophilin t...
| Class:Id | Summation:8875486 |
|---|---|
| _displayName | CBL recruits the complex of SH3KBP1 (CIN85) and endophilin t... |
| _timestamp | 2016-06-13 17:44:37 |
| created | [InstanceEdit:8875485] Orlic-Milacic, Marija, 2016-06-06 |
| literatureReference | [LiteratureReference:8875449] The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met [LiteratureReference:2076226] Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes |
| modified | [InstanceEdit:8876345] Orlic-Milacic, Marija, 2016-06-13 |
| text | CBL recruits the complex of SH3KBP1 (CIN85) and endophilin to the activated MET receptor. While CIN85 and endophilin are not involved in CBL tyrosine phosphorylation by activated MET and CBL-mediated MET ubiquitination, they are required for internalization and degradation of the activated MET receptor (Petrelli et al. 2002). CIN85 likely functions as a homotetramer (Watanabe et al. 2000). Endophilin A1 (SH3GL2), A2 (SH3GL1) and A3 (SH3GL3), which function as homodimers, can all be recruited to the activated MET receptor, with SH3GL3 being the most extensively studied (Petrelli et al. 2002). |
| (summation) | [Reaction:8875482] CBL recruits CIN85:endophilin to ubiquitinated MET [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by CBL recruits the complex of SH3KBP1 (CIN85) and endophilin t... (8875486)
