Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person MET phosphorylates CBL

Class:IdReaction:8875451
_displayNameMET phosphorylates CBL
_doReleaseTRUE
_timestamp2016-07-19 17:47:23
authored[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
catalystActivity[CatalystActivity:8875458] protein tyrosine kinase activity of HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:8875452] Orlic-Milacic, Marija, 2016-06-05
edited[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
input[CandidateSet:8876353] HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:8875449] The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met
[LiteratureReference:8874693] Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
modified[InstanceEdit:8875460] Orlic-Milacic, Marija, 2016-06-05
[InstanceEdit:8876359] Orlic-Milacic, Marija, 2016-06-13
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8931694] Orlic-Milacic, Marija, 2016-07-18
[InstanceEdit:8931945] Orlic-Milacic, Marija, 2016-07-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMET phosphorylates CBL
output[SimpleEntity:29370] ADP [cytosol]
[CandidateSet:8876355] HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2016-09-19
reviewed[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11
[InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8926507] R-HSA-8875451.2
summation[Summation:8875447] MET phosphorylates CBL on unknown tyrosine residues. This is...
(hasEvent)[Pathway:6807004] Negative regulation of MET activity [Homo sapiens]
(inferredFrom)[Reaction:8876246] InlB-activated MET phosphorylates CBL [Homo sapiens]
(precedingEvent)[Reaction:8875183] CBL monoubiquitinates activated MET [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by MET phosphorylates CBL (8875451)