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Details on Person Diagram of Listeria monocytogenes entry into host cells

Class:IdPathwayDiagram:8875366
_displayNameDiagram of Listeria monocytogenes entry into host cells
_timestamp2020-09-09 14:29:45
created[InstanceEdit:8875367] Orlic-Milacic, Marija, 2016-06-03
height591
modified[InstanceEdit:8876218] Orlic-Milacic, Marija, 2016-06-10
[InstanceEdit:8876234] Orlic-Milacic, Marija, 2016-06-10
[InstanceEdit:8876239] Orlic-Milacic, Marija, 2016-06-10
[InstanceEdit:8876243] Orlic-Milacic, Marija, 2016-06-10
[InstanceEdit:8876249] Orlic-Milacic, Marija, 2016-06-10
[InstanceEdit:8876259] Orlic-Milacic, Marija, 2016-06-10
[InstanceEdit:8876264] Orlic-Milacic, Marija, 2016-06-10
[InstanceEdit:8876265] Orlic-Milacic, Marija, 2016-06-10
[InstanceEdit:8876381] Orlic-Milacic, Marija, 2016-06-14
[InstanceEdit:8876385] Orlic-Milacic, Marija, 2016-06-14
[InstanceEdit:8876400] Orlic-Milacic, Marija, 2016-06-14
[InstanceEdit:8876495] Orlic-Milacic, Marija, 2016-06-15
[InstanceEdit:8876507] Orlic-Milacic, Marija, 2016-06-15
[InstanceEdit:8876918] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8876923] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8876937] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8876949] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8876971] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8876995] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8877001] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8877014] Orlic-Milacic, Marija, 2016-06-17
[InstanceEdit:8877848] Orlic-Milacic, Marija, 2016-06-28
[InstanceEdit:8877852] Orlic-Milacic, Marija, 2016-06-28
[InstanceEdit:9634814] Rothfels, Karen, 2019-01-15
[InstanceEdit:9637765] Orlic-Milacic, Marija, 2019-02-19
[InstanceEdit:9638089] Orlic-Milacic, Marija, 2019-02-25
[InstanceEdit:9638151] Orlic-Milacic, Marija, 2019-02-27
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9699059] Matthews, Lisa, 2020-09-09
representedPathway[Pathway:8876384] Listeria monocytogenes entry into host cells [Homo sapiens]
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<displayName>cell wall</displayName> </Properties> <Components> <Component id="478" /> <Component id="675" /> <Component id="857" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="475" reactomeId="70101" position="1125 365" bounds="55 147 2140 436" textPosition="121 522" bgColor="250 240 240" lineColor="255 153 102" insets="89 321 2082 246"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="471" /> <Component id="472" /> <Component id="473" /> <Component id="479" /> <Component id="488" /> <Component id="489" /> <Component id="512" /> <Component id="513" /> <Component id="511" /> <Component id="510" /> <Component id="546" /> <Component id="548" /> <Component id="567" /> <Component id="568" /> <Component id="569" /> <Component id="570" /> <Component id="583" /> <Component id="585" /> <Component id="599" /> <Component id="600" /> <Component id="598" /> <Component id="621" /> <Component id="622" /> <Component id="623" /> <Component id="624" /> <Component id="673" /> <Component id="676" /> <Component id="705" /> <Component id="706" /> <Component id="707" /> <Component id="708" /> <Component id="709" /> <Component id="748" /> <Component id="750" /> <Component id="751" /> <Component id="770" /> <Component id="787" /> <Component id="788" /> <Component id="789" /> <Component id="838" /> <Component id="839" /> <Component id="840" /> <Component id="841" /> <Component id="842" /> <Component id="843" /> <Component id="860" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.Note id="478" position="331 57" bounds="241 44 181 26" textPosition="258 46"> <Properties> <isChanged>true</isChanged> <displayName>Listeria monocytogenes</displayName> </Properties> </org.gk.render.Note> <org.gk.render.Note id="479" position="151 517" bounds="101 506 101 23" textPosition="122 507"> <Properties> <isChanged>true</isChanged> <displayName>Host cell</displayName> </Properties> </org.gk.render.Note> <org.gk.render.RenderableComplex id="489" reactomeId="8876211" position="529 145" bounds="479 134 101 22" textPosition="482 135" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlB:MET dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="511" reactomeId="113592" position="594 197" bounds="573 185 42 25" textPosition="579 187" /> <org.gk.render.RenderableChemical id="512" reactomeId="29370" position="691 204" bounds="669 192 44 24" textPosition="675 193" /> <org.gk.render.RenderableComplex id="513" reactomeId="8876231" position="774 147" bounds="725 129 99 36" textPosition="725 130" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlB:p-4Y-MET dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="548" reactomeId="8876242" position="1014 157" bounds="945 138 138 39" textPosition="946 142" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlB:p-4Y-MET dimer:GRB2-1:CBL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="568" reactomeId="113592" position="1107 194" bounds="1086 180 42 28" textPosition="1092 183"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="569" reactomeId="29370" position="1259 194" bounds="1238 179 43 30" textPosition="1243 183"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="570" reactomeId="8876247" position="1371 154" bounds="1295 137 152 34" textPosition="1303 136" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlB:p-4Y-MET dimer:GRB2-1:p-Y-CBL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="585" reactomeId="8876253" position="1631 154" bounds="1562 125 138 58" textPosition="1562 134" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="599" reactomeId="8875480" position="1712 227" bounds="1671 210 82 35" textPosition="1677 210" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CIN85:endophilin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="600" reactomeId="8876251" position="1841 159" bounds="1770 126 142 66" textPosition="1772 129" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL:CIN85:endophilin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="622" reactomeId="182947" position="1932 222" bounds="1891 205 82 34" textPosition="1895 204" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EPS15:HGS:STAM</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="623" reactomeId="8876263" position="2098 156" bounds="2023 123 150 67" textPosition="2028 127" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlB:MonoUb-K,p-4Y-MET:GRB2-1:p-Y-CBL:CIN85:endophilin:EPS15:HGS:STAM</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="624" reactomeId="182910" position="846 215" bounds="813 204 66 22" textPosition="814 205" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CBL:GRB2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="675" reactomeId="8876505" position="100 109" bounds="79 98 42 22" textPosition="84 98"> <Properties> <displayName>InlA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="676" reactomeId="8876504" position="299 217" bounds="233 199 133 37" textPosition="237 201" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlA:CDH1:CTNNB1:CTNND1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="706" reactomeId="113592" position="240 340" bounds="220 325 40 30" textPosition="225 329" /> <org.gk.render.RenderableProtein id="707" reactomeId="8876922" position="143 303" bounds="104 292 79 22" textPosition="109 292"> <Properties> <displayName>MyrG-SRC</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.22151898734177214" relativeY="0.0" label="My" trackId="0" reactomeId="1810396" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="708" reactomeId="1810408" position="428 304" bounds="363 292 131 25" textPosition="369 294"> <Properties> <displayName>MyrG-p-Y419-SRC</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.13358778625954199" relativeY="0.0" label="My" trackId="0" reactomeId="1810396" /> <org.gk.render.RenderableFeature relativeX="0.26717557251908397" relativeY="0.0" label="P" trackId="0" reactomeId="1810398" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="709" reactomeId="29370" position="343 347" bounds="323 332 41 30" textPosition="327 336" /> <org.gk.render.RenderableComplex id="750" reactomeId="8876941" position="629 257" bounds="549 238 160 38" textPosition="550 241" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CTNND1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="751" reactomeId="29370" position="487 262" bounds="467 247 41 30" textPosition="471 251" /> <org.gk.render.RenderableChemical id="770" reactomeId="113592" position="379 262" bounds="359 247 40 30" textPosition="364 251" /> <org.gk.render.RenderableComplex id="788" reactomeId="8876991" position="799 354" bounds="754 336 90 36" textPosition="756 337" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CBLL1 dimer:Zn2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="789" reactomeId="8876983" position="1071 259" bounds="975 239 193 41" textPosition="978 245" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="839" reactomeId="8877010" position="1467 267" bounds="1352 246 230 42" textPosition="1353 253" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="2.0" isForDisease="true" hideComponents="true"> <Properties> <displayName>InlA:Ub-K,p-Y753,Y754-CDH1:Ub-K,p-Y-CTNNB1:CBLL1 dimer:Zn2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.Note id="840" position="137 264" bounds="65 253 144 22" textPosition="80 253"> <Properties> <isChanged>true</isChanged> <displayName>plasma membrane</displayName> </Properties> </org.gk.render.Note> <org.gk.render.Note id="841" position="133 241" bounds="83 230 101 23" textPosition="104 231"> <Properties> <isChanged>true</isChanged> <displayName>Host cell</displayName> </Properties> </org.gk.render.Note> <org.gk.render.RenderableComplex id="842" reactomeId="8877851" position="65 198" bounds="15 180 100 36" textPosition="16 181" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CDH1:CTNNB1:CTNND1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="843" reactomeId="418996" position="951 317" bounds="921 306 60 22" textPosition="922 306"> <Properties> <displayName>CTNND1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="857" reactomeId="9637757" position="183 101" bounds="166 90 35 22" textPosition="169 90" isForDisease="true" lineColor="255 0 0"> <Properties> <displayName>InlB</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="860" reactomeId="113595" position="1371 215" bounds="1348 202 46 27" textPosition="1359 205"> <Properties> <displayName>Ub</displayName> </Properties> </org.gk.render.RenderableEntitySet> </Nodes> <Edges> <org.gk.render.RenderableReaction id="473" reactomeId="8875371" points="242 160, 262 158, 305 151" position="262 158" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="471" points="198 165" /> <Input id="857" points="194 118" /> </Inputs> <Outputs> <Output id="472" /> </Outputs> <Properties> <displayName>InlB binds MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="488" reactomeId="8876210" points="401 147, 452 150, 476 148" position="452 150" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="472" stoichiometry="2" /> </Inputs> <Outputs> <Output id="489" /> </Outputs> <Properties> <displayName>InlB promotes MET dimerization</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="510" reactomeId="8876230" points="616 151, 640 153, 670 154" position="640 153" lineWidth="2.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="489" points="583 148" /> <Input id="511" stoichiometry="8" points="599 182" /> </Inputs> <Outputs> <Output id="512" stoichiometry="8" points="685 189" /> <Output id="513" points="722 150" /> </Outputs> <Catalysts> <Catalyst id="489" points="570 131, 608 124" /> </Catalysts> <Properties> <displayName>InlB:MET dimer trans-autophophorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="546" reactomeId="8876240" points="865 157, 897 156, 942 156" position="897 156" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="513" points="827 152" /> <Input id="624" points="849 201" /> </Inputs> <Outputs> <Output id="548" /> </Outputs> <Properties> <displayName>CBL binds InlB-activated MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="567" reactomeId="8876246" points="1131 154, 1179 154, 1219 155" position="1179 154" lineWidth="2.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="568" points="1115 177" /> <Input id="548" points="1086 155" /> </Inputs> <Outputs> <Output id="569" points="1243 176" /> <Output id="570" points="1292 154" /> </Outputs> <Catalysts> <Catalyst id="548" points="1077 135, 1155 114" /> </Catalysts> <Properties> <displayName>InlB-activated MET phosphorylates CBL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="583" reactomeId="8876258" points="1495 159, 1532 160, 1559 158" position="1532 160" lineWidth="2.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="570" points="1450 157" /> <Input id="860" stoichiometry="2" points="1400 204" /> </Inputs> <Outputs> <Output id="585" /> </Outputs> <Catalysts> <Catalyst id="570" points="1436 134, 1505 119" /> </Catalysts> <Properties> <displayName>CBL monoubiquitinates InlB-bound MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="598" reactomeId="8876255" points="1727 167, 1745 165, 1767 163" position="1745 165" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="585" points="1703 163" /> <Input id="599" points="1716 207" /> </Inputs> <Outputs> <Output id="600" /> </Outputs> <Properties> <displayName>CBL recruits CIN85:endophilin complex to InlB-bound MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="621" reactomeId="8876262" points="1961 156, 1978 161, 2020 159" position="1978 161" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="600" points="1915 157" /> <Input id="622" points="1939 202" /> </Inputs> <Outputs> <Output id="623" /> </Outputs> <Properties> <displayName>EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="673" reactomeId="8876497" points="139 191, 151 206, 230 212" position="151 206" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="675" points="105 123" /> <Input id="842" points="118 193" /> </Inputs> <Outputs> <Output id="676" /> </Outputs> <Properties> <displayName>InlA binds CDH1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="705" reactomeId="112333" points="256 299, 297 300, 336 297" position="297 300" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="706" points="245 322" /> <Input id="707" points="186 301" /> </Inputs> <Outputs> <Output id="708" points="360 299" /> <Output id="709" points="340 329" /> </Outputs> <Catalysts> <Catalyst id="707" points="186 295, 253 281" /> </Catalysts> <Activators> <Activator id="676" points="298 239" /> </Activators> <Properties> <displayName>SRC autophosphorylation is positively regulated by InlA-bound CDH1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="748" reactomeId="8876948" points="399 212, 430 212, 466 213" position="430 212" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="770" stoichiometry="5" points="385 244" /> <Input id="676" points="369 213" /> </Inputs> <Outputs> <Output id="750" points="558 235" /> <Output id="751" stoichiometry="5" points="480 244" /> </Outputs> <Catalysts> <Catalyst id="708" points="428 289" /> </Catalysts> <Properties> <displayName>SRC phosphorylates InlA-bound CDH1 and CTNNB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="787" reactomeId="8876993" points="800 299, 832 285, 902 277" position="832 285" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="750" points="706 279" /> <Input id="788" points="799 333" /> </Inputs> <Outputs> <Output id="843" points="937 303" /> <Output id="789" points="972 269" /> </Outputs> <Properties> <displayName>CBLL1 binds SRC-phosphorylated CDH1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="838" reactomeId="8877003" points="1226 260, 1281 268, 1349 267" position="1281 268" lineWidth="2.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="789" points="1171 259" /> <Input id="860" stoichiometry="3" points="1342 222" /> </Inputs> <Outputs> <Output id="839" /> </Outputs> <Catalysts> <Catalyst id="789" points="1171 279, 1213 289" /> </Catalysts> <Properties> <displayName>CBLL1 ubiqutinates the InlA-bound CDH1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Listeria monocytogenes entry into host cells (8875366)
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