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Details on Person CBL monoubiquitinates activated MET receptor probably at mul...

Class:IdSummation:8875353
_displayNameCBL monoubiquitinates activated MET receptor probably at mul...
_timestamp2016-06-03 19:46:56
created[InstanceEdit:8875358] Orlic-Milacic, Marija, 2016-06-03
textCBL monoubiquitinates activated MET receptor probably at multiple lysine residues, triggering MET endocytosis and degradation through the lysosomal route (Abella et al. 2005, Veiga and Cossart 2005). InlB, a cell wall protein of Listeria monocytogenes, binds to MET receptor as an HGF agonist. The subsequent CBL-mediated monoubiquitination of MET promotes endocytosis of bacteria and entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).
(summation)[Reaction:8875183] CBL monoubiquitinates activated MET [Homo sapiens]
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