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Details on Person CBL monoubiquitinates activated MET

Class:Id	Reaction:8875183
_displayName	CBL monoubiquitinates activated MET
_doRelease	TRUE
_timestamp	2019-01-15 13:50:40
authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
catalystActivity	[CatalystActivity:8875354] ubiquitin protein ligase activity of HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8875186] Orlic-Milacic, Marija, 2016-06-02
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
input	[CandidateSet:8876355] HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8875182] Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation [LiteratureReference:8875355] Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells
modified	[InstanceEdit:8875359] Orlic-Milacic, Marija, 2016-06-03 [InstanceEdit:8875454] Orlic-Milacic, Marija, 2016-06-05 [InstanceEdit:8875460] Orlic-Milacic, Marija, 2016-06-05 [InstanceEdit:8876359] Orlic-Milacic, Marija, 2016-06-13 [InstanceEdit:8876377] Orlic-Milacic, Marija, 2016-06-14 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8931694] Orlic-Milacic, Marija, 2016-07-18 [InstanceEdit:8931945] Orlic-Milacic, Marija, 2016-07-19 [InstanceEdit:9634772] Rothfels, Karen, 2019-01-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CBL monoubiquitinates activated MET
output	[CandidateSet:8876375] HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8875451] MET phosphorylates CBL [Homo sapiens] [Reaction:8874685] CBL binds MET [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8901313] R-HSA-8875183.3
summation	[Summation:8875353] CBL monoubiquitinates activated MET receptor probably at mul...
(hasEvent)	[Pathway:6807004] Negative regulation of MET activity [Homo sapiens]
(precedingEvent)	[Reaction:8875482] CBL recruits CIN85:endophilin to ubiquitinated MET [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778277] Update Tracker - [Reaction:8875183] CBL monoubiquitinates activated MET - v68:[add_removeInput]
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No pathways have been reviewed or authored by CBL monoubiquitinates activated MET (8875183)