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Details on Person TFAP2C homodimer binds the EGFR gene promoter

Class:Id	Reaction:8874789
_displayName	TFAP2C homodimer binds the EGFR gene promoter
_doRelease	TRUE
_timestamp	2016-08-15 17:33:32
authored	[InstanceEdit:8864334] Orlic-Milacic, Marija, 2016-03-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8874791] Orlic-Milacic, Marija, 2016-05-27
edited	[InstanceEdit:8864334] Orlic-Milacic, Marija, 2016-03-14
input	[Complex:8864386] TFAP2C homodimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8874800] EGFR gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8874784] EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib [LiteratureReference:8874801] The role of Tcfap2c in tumorigenesis and cancer growth in an activated Neu model of mammary carcinogenesis
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933630] Orlic-Milacic, Marija, 2016-08-08 [InstanceEdit:8935913] Orlic-Milacic, Marija, 2016-08-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TFAP2C homodimer binds the EGFR gene promoter
output	[Complex:8874796] TFAP2C homodimer:EGFR gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8864278] AP-2 (TFAP2) transcription factors form homo- and heterodimers [Homo sapiens] [Reaction:8864577] TFAP2C translocates to the nucleus [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8874793] Bogachek, Maria V, 2016-05-17 [InstanceEdit:8874798] Weigel, Ronald J, 2016-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8894800] R-HSA-8874789.2
summation	[Summation:8874790] TFAP2C (AP-2 gamma) homodimer binds the promoter region of t...
(hasEvent)	[Pathway:8866910] TFAP2 (AP-2) family regulates transcription of growth factors and their receptors [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8874797] EGFR gene expression is stimulated by TFAP2C [Homo sapiens]
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No pathways have been reviewed or authored by TFAP2C homodimer binds the EGFR gene promoter (8874789)