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Details on Person CBL binds MET

Class:Id	Reaction:8874685
_displayName	CBL binds MET
_doRelease	TRUE
_timestamp	2016-07-19 17:47:21
authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8874680] Orlic-Milacic, Marija, 2016-05-25
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
input	[CandidateSet:8874682] HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] [Homo sapiens] [CandidateSet:8876356] CBL:GRB2,CBL [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8874693] Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein [LiteratureReference:8874700] c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination [LiteratureReference:8874699] A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation [LiteratureReference:8875182] Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation
modified	[InstanceEdit:8875090] Orlic-Milacic, Marija, 2016-06-01 [InstanceEdit:8875187] Orlic-Milacic, Marija, 2016-06-02 [InstanceEdit:8876359] Orlic-Milacic, Marija, 2016-06-13 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8931694] Orlic-Milacic, Marija, 2016-07-18 [InstanceEdit:8931945] Orlic-Milacic, Marija, 2016-07-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CBL binds MET
output	[CandidateSet:8876353] HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:6806974] MET dimers autophosphorylate [Homo sapiens] [Reaction:6806957] MET receptor dimerizes [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8897612] R-HSA-8874685.2
summation	[Summation:8875085] The E3 ubiquitin ligase CBL can bind to the MET receptor eit...
(hasEvent)	[Pathway:6807004] Negative regulation of MET activity [Homo sapiens]
(precedingEvent)	[Reaction:8875451] MET phosphorylates CBL [Homo sapiens]
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No pathways have been reviewed or authored by CBL binds MET (8874685)