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Details on Person MBTPS1 (S1P) cleaves CREB3L3

Class:Id	Reaction:8874206
_displayName	MBTPS1 (S1P) cleaves CREB3L3
_doRelease	TRUE
_timestamp	2017-02-25 10:05:32
authored	[InstanceEdit:8874189] May, Bruce, 2016-05-21
catalystActivity	[CatalystActivity:380995] serine-type endopeptidase activity of MBTPS1 [Golgi membrane]
catalystActivityReference	[CatalystActivityReference:9643125] serine-type endopeptidase activity of MBTPS1 [Golgi membrane] ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:8874199] May, Bruce, 2016-05-21
edited	[InstanceEdit:8874189] May, Bruce, 2016-05-21
input	[EntityWithAccessionedSequence:8874144] CREB3L3 [Golgi membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6784849] Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6 [LiteratureReference:8874246] Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis [LiteratureReference:6784687] Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
modified	[InstanceEdit:8874323] May, Bruce, 2016-05-22 [InstanceEdit:8874415] May, Bruce, 2016-05-23 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933466] May, Bruce, 2016-08-04 [InstanceEdit:8934411] May, Bruce, 2016-08-09 [InstanceEdit:8979371] May, Bruce, 2017-02-25 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MBTPS1 (S1P) cleaves CREB3L3
output	[EntityWithAccessionedSequence:8874158] CREB3L3(1-364) [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:8874130] CREB3L3(365-461) [Golgi membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8874208] CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8979366] Schr�der, M, 2017-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8897534] R-HSA-8874206.3
summation	[Summation:8874379] CREB3L3 at the Golgi membrane is cleaved in the luminal doma...
(hasEvent)	[Pathway:8874211] CREB3 factors activate genes [Homo sapiens]
(precedingEvent)	[Reaction:8874201] MBTPS2 (S2P) cleaves CREB3L3 [Homo sapiens]
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No pathways have been reviewed or authored by MBTPS1 (S1P) cleaves CREB3L3 (8874206)