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Details on Person MBTPS2 (S2P) cleaves CREB3L3

Class:IdReaction:8874201
_displayNameMBTPS2 (S2P) cleaves CREB3L3
_doReleaseTRUE
_timestamp2017-02-25 10:06:56
authored[InstanceEdit:8874189] May, Bruce, 2016-05-21
catalystActivity[CatalystActivity:381068] metalloendopeptidase activity of MBTPS2 [Golgi membrane]
catalystActivityReference[CatalystActivityReference:9643102] metalloendopeptidase activity of MBTPS2 [Golgi membrane] ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
compartment[Compartment:20699] Golgi membrane
[Compartment:70101] cytosol
created[InstanceEdit:8874199] May, Bruce, 2016-05-21
edited[InstanceEdit:8874189] May, Bruce, 2016-05-21
input[EntityWithAccessionedSequence:8874158] CREB3L3(1-364) [Golgi membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8874246] Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis
[LiteratureReference:6784687] Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
modified[InstanceEdit:8874323] May, Bruce, 2016-05-22
[InstanceEdit:8874415] May, Bruce, 2016-05-23
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8933466] May, Bruce, 2016-08-04
[InstanceEdit:8934411] May, Bruce, 2016-08-09
[InstanceEdit:8979371] May, Bruce, 2017-02-25
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMBTPS2 (S2P) cleaves CREB3L3
output[EntityWithAccessionedSequence:8874214] CREB3L3(1-323) [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:8874183] CREB3L3(324-364) [Golgi membrane] [Homo sapiens]
precedingEvent
releaseDate2017-03-27
reviewed[InstanceEdit:8979366] Schröder, M, 2017-02-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8906509] R-HSA-8874201.3
summation[Summation:8874389] After cleavage by MBTPS1, CREB3L3 in the Golgi membrane is c...
(hasEvent)[Pathway:8874211] CREB3 factors activate genes [Homo sapiens]
(precedingEvent)[BlackBoxEvent:8874202] CREB3L3 translocates from the cytosol to the nucleus [Homo sapiens]
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No pathways have been reviewed or authored by MBTPS2 (S2P) cleaves CREB3L3 (8874201)