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Details on Person CREB3L1 translocates from the cytosol to the nucleus

Class:Id	BlackBoxEvent:8874193
_displayName	CREB3L1 translocates from the cytosol to the nucleus
_doRelease	TRUE
_timestamp	2017-03-01 06:59:23
authored	[InstanceEdit:8874189] May, Bruce, 2016-05-21
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:8874199] May, Bruce, 2016-05-21
edited	[InstanceEdit:8874189] May, Bruce, 2016-05-21
inferredFrom	[BlackBoxEvent:8874373] Creb3l1 (Oasis) translocates from the cytosol to the nucleus [Mus musculus]
input	[EntityWithAccessionedSequence:8874215] CREB3L1(1-375) [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8936302] Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers [LiteratureReference:8936281] OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro [LiteratureReference:8936325] The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells
modified	[InstanceEdit:8874323] May, Bruce, 2016-05-22 [InstanceEdit:8874415] May, Bruce, 2016-05-23 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933466] May, Bruce, 2016-08-04 [InstanceEdit:8934411] May, Bruce, 2016-08-09 [InstanceEdit:8936303] May, Bruce, 2016-08-17 [InstanceEdit:8936326] May, Bruce, 2016-08-17 [InstanceEdit:8979371] May, Bruce, 2017-02-25 [InstanceEdit:8980864] Matthews, Lisa, 2017-03-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CREB3L1 translocates from the cytosol to the nucleus
output	[EntityWithAccessionedSequence:8874222] CREB3L1(1-375) [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8874194] MBTPS2 (S2P) cleaves CREB3L1 [Homo sapiens] [Reaction:8874212] MBTPS1 (S1P) cleaves CREB3L1 [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8979366] Schr�der, M, 2017-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8893941] R-HSA-8874193.2
summation	[Summation:8874365] Cleavage by MBTPS2 releases the N-terminal domain of CREB3L1...
(hasEvent)	[Pathway:8874211] CREB3 factors activate genes [Homo sapiens]
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No pathways have been reviewed or authored by CREB3L1 translocates from the cytosol to the nucleus (8874193)