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Details on Person MBTPS1 (S1P) cleaves CREB3L4

Class:IdReaction:8874186
_displayNameMBTPS1 (S1P) cleaves CREB3L4
_doReleaseTRUE
_timestamp2017-02-25 10:05:48
authored[InstanceEdit:8874189] May, Bruce, 2016-05-21
catalystActivity[CatalystActivity:380995] serine-type endopeptidase activity of MBTPS1 [Golgi membrane]
catalystActivityReference[CatalystActivityReference:9643125] serine-type endopeptidase activity of MBTPS1 [Golgi membrane] ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
compartment[Compartment:20699] Golgi membrane
created[InstanceEdit:8874199] May, Bruce, 2016-05-21
edited[InstanceEdit:8874189] May, Bruce, 2016-05-21
inferredFrom
input[EntityWithAccessionedSequence:8874128] CREB3L4 [Golgi membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8874166] CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P
[LiteratureReference:8874315] Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells
modified[InstanceEdit:8874323] May, Bruce, 2016-05-22
[InstanceEdit:8874832] May, Bruce, 2016-05-29
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8933466] May, Bruce, 2016-08-04
[InstanceEdit:8934411] May, Bruce, 2016-08-09
[InstanceEdit:8979371] May, Bruce, 2017-02-25
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMBTPS1 (S1P) cleaves CREB3L4
output[EntityWithAccessionedSequence:8874180] CREB3L4(1-338) [Golgi membrane] [Homo sapiens]
[EntityWithAccessionedSequence:8874140] CREB3L4(339-395) [Golgi membrane] [Homo sapiens]
precedingEvent
releaseDate2017-03-27
reviewed[InstanceEdit:8979366] Schröder, M, 2017-02-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8929198] R-HSA-8874186.3
summation[Summation:8874817] MBTPS1 (S1P) cleaves the lumenal domain of CREB3L4 (Stirling...
(hasEvent)[Pathway:8874211] CREB3 factors activate genes [Homo sapiens]
(precedingEvent)[Reaction:8874195] MBTPS2 (S2P) cleaves CREB3L4 [Homo sapiens]
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