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Details on Person p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP

Class:IdReaction:8871366
_displayNamep-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP
_doReleaseTRUE
_timestamp2025-08-13 21:47:39
authored[InstanceEdit:8871368] Jassal, Bijay, 2016-05-16
catalystActivity[CatalystActivity:9960150] protein-macromolecule adaptor activity of p-Y389,400-RUFY1 [early endosome membrane]
catalystActivityReference[CatalystActivityReference:9960149] protein-macromolecule adaptor activity of p-Y389,400-RUFY1 [early endosome membrane] Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4
compartment[Compartment:171062] early endosome membrane
created[InstanceEdit:8871368] Jassal, Bijay, 2016-05-16
edited[InstanceEdit:8871368] Jassal, Bijay, 2016-05-16
input[EntityWithAccessionedSequence:5215951] p-Y389,400-RUFY1 [early endosome membrane] [Homo sapiens]
[Complex:8871377] RAB14:GTP [early endosome membrane] [Homo sapiens]
[Complex:8871367] RAB4A:GTP [early endosome membrane] [Homo sapiens]
[Complex:2130191] RAB5A:GTP [early endosome membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9960221] D'Eustachio, Peter, 2025-07-07
isChimericFALSE
literatureReference[LiteratureReference:8871351] RUFY, Rab and Rap Family Proteins Involved in a Regulation of Cell Polarity and Membrane Trafficking
[LiteratureReference:8871369] Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
[LiteratureReference:8871382] Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes
[LiteratureReference:8871392] The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes
[LiteratureReference:9960151] Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4
modified[InstanceEdit:8871387] Jassal, Bijay, 2016-05-16
[InstanceEdit:8871397] Jassal, Bijay, 2016-05-16
[InstanceEdit:8879142] Jassal, Bijay, 2016-07-15
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8932134] Jassal, Bijay, 2016-07-21
[InstanceEdit:8933572] Jassal, Bijay, 2016-08-08
[InstanceEdit:8935821] Jassal, Bijay, 2016-08-15
[InstanceEdit:9822865] D'Eustachio, Peter, 2022-12-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9960148] D'Eustachio, Peter, 2025-07-07
[InstanceEdit:9960220] D'Eustachio, Peter, 2025-07-07
[InstanceEdit:9963237] D'Eustachio, Peter, 2025-08-13
namep-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP
output[Complex:8871353] p-Y389,400-RUFY1:p-Y389,400-RUFY1:RAB4A:GTP:RAB5:GTP:RAB14:GTP [early endosome membrane] [Homo sapiens]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2016-09-19
reviewed[InstanceEdit:8879141] D'Eustachio, Peter, 2016-07-15
[InstanceEdit:9963238] Hill, David P, 2025-08-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8888811] R-HSA-8871366.4
structureModified[InstanceEdit:9960148] D'Eustachio, Peter, 2025-07-07
summation[Summation:8871349] RUN and FYVE domain-containing protein 1 (RUFY1, aka RABIP4,...
(hasEvent)[Pathway:1660499] Synthesis of PIPs at the plasma membrane [Homo sapiens]
(updatedInstance)[_UpdateTracker:9964746] Update Tracker - [Reaction:8871366] p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP - v94:[modifyText, removeCatalystActivity, removeLiteratureReference]
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