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Query author contributions in Reactome

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Details on Person APP gene expression

Class:IdBlackBoxEvent:8870710
_displayNameAPP gene expression
_doReleaseTRUE
_timestamp2025-07-16 18:44:49
authored[InstanceEdit:8862798] Shah, Kavita, 2016-02-23
compartment[Compartment:984] extracellular region
[Compartment:7660] nucleoplasm
created[InstanceEdit:8870713] Orlic-Milacic, Marija, 2016-05-11
disease[Disease:8863054] Alzheimer's disease
edited[InstanceEdit:8870719] Orlic-Milacic, Marija, 2016-05-11
input[EntityWithAccessionedSequence:8870711] APP gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9960788] Cdk5-Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
modified[InstanceEdit:8870718] Orlic-Milacic, Marija, 2016-05-11
[InstanceEdit:8870719] Orlic-Milacic, Marija, 2016-05-11
[InstanceEdit:8870769] Orlic-Milacic, Marija, 2016-05-11
[InstanceEdit:8870770] Orlic-Milacic, Marija, 2016-05-11
[InstanceEdit:8870818] Orlic-Milacic, Marija, 2016-05-12
[InstanceEdit:8875080] Orlic-Milacic, Marija, 2016-06-01
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9960789] D'Eustachio, Peter, 2025-07-16
nameAPP gene expression
output[EntityWithAccessionedSequence:879340] APP(672-713) [extracellular region] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:8870712] Positive regulation by 'p-S43,S173,S294,S325-FOXO3 [nucleoplasm]'
regulationReference[RegulationReference:9642277] Positive regulation by 'p-S43,S173,S294,S325-FOXO3 [nucleoplasm]' Cdk5-Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
releaseDate2016-09-19
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8882645] R-HSA-8870710.5
summation[Summation:8870717] Transcription of the APP gene is increased by FOXO3, downstr...
(hasEvent)[Pathway:8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models [Homo sapiens]
(updatedInstance)[_UpdateTracker:9964754] Update Tracker - [BlackBoxEvent:8870710] APP gene expression - v94:[add_removeLiteratureReference]
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No pathways have been reviewed or authored by APP gene expression (8870710)