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Details on Person Phosphorylated FOXO3 translocates to the nucleus

Class:Id	Reaction:8870628
_displayName	Phosphorylated FOXO3 translocates to the nucleus
_doRelease	TRUE
_timestamp	2025-07-16 18:44:54
authored	[InstanceEdit:8862798] Shah, Kavita, 2016-02-23
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:8870629] Orlic-Milacic, Marija, 2016-05-10
disease	[Disease:8863054] Alzheimer's disease
edited	[InstanceEdit:8870719] Orlic-Milacic, Marija, 2016-05-11
input	[EntityWithAccessionedSequence:8870560] p-S43,S173,S294,S325-FOXO3 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9960788] Cdk5-Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
modified	[InstanceEdit:8870670] Orlic-Milacic, Marija, 2016-05-10 [InstanceEdit:8870673] Orlic-Milacic, Marija, 2016-05-10 [InstanceEdit:8870769] Orlic-Milacic, Marija, 2016-05-11 [InstanceEdit:8870818] Orlic-Milacic, Marija, 2016-05-12 [InstanceEdit:8875080] Orlic-Milacic, Marija, 2016-06-01 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9960789] D'Eustachio, Peter, 2025-07-16
name	Phosphorylated FOXO3 translocates to the nucleus
output	[EntityWithAccessionedSequence:8870627] p-S43,S173,S294,S325-FOXO3 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8870558] CDK5:p25 phosphorylates FOXO3 [Homo sapiens] [Reaction:8863013] CDK5 binds p25 [Homo sapiens]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8891293] R-HSA-8870628.3
summation	[Summation:8870671] CDK5-mediated phosphorylation of the transcription factor FO...
(hasEvent)	[Pathway:8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8870686] BCL2L11 (BIM) gene expression [Homo sapiens] [BlackBoxEvent:8870698] FASLG (FasL) gene expression [Homo sapiens] [BlackBoxEvent:8870703] SOD2 (MnSOD) gene expression [Homo sapiens] [BlackBoxEvent:8870710] APP gene expression [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9964774] Update Tracker - [Reaction:8870628] Phosphorylated FOXO3 translocates to the nucleus - v94:[add_removeLiteratureReference]
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