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Details on Person RGGT binds the RAB-binding subunit

Class:Id	Reaction:8870465
_displayName	RGGT binds the RAB-binding subunit
_doRelease	TRUE
_timestamp	2016-11-17 21:22:34
authored	[InstanceEdit:8875718] Rothfels, Karen, 2016-06-08
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8870464] Rothfels, Karen, 2016-05-09
edited	[InstanceEdit:8875718] Rothfels, Karen, 2016-06-08
input	[Complex:8870460] RABGGTA:RABGGTB [cytosol] [Homo sapiens] [DefinedSet:8870446] CHMs [cytosol] [Homo sapiens] [SimpleEntity:1131164] geranylgeranyl diphosphate [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6801102] Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate [LiteratureReference:8870364] Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein [LiteratureReference:8870365] Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases [LiteratureReference:8935807] Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II [LiteratureReference:6801119] Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1 [LiteratureReference:8935810] cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein
modified	[InstanceEdit:8875722] Rothfels, Karen, 2016-06-08 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933443] Rothfels, Karen, 2016-08-04 [InstanceEdit:8935816] Rothfels, Karen, 2016-08-15 [InstanceEdit:8936084] Rothfels, Karen, 2016-08-16 [InstanceEdit:8936120] Rothfels, Karen, 2016-08-16 [InstanceEdit:8943256] Rothfels, Karen, 2016-10-24 [InstanceEdit:8948923] Rothfels, Karen, 2016-11-17 [InstanceEdit:8948929] Rothfels, Karen, 2016-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RGGT binds the RAB-binding subunit
output	[Complex:8870462] RABGGTA:RABGGTB:CHMs:GGPP [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8870461] RABGGTA and RABGGTB bind [Homo sapiens]
releaseDate	2016-12-12
reviewed	[InstanceEdit:8933435] Palsuledesai, Charuta C, 2016-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8900532] R-HSA-8870465.2
summation	[Summation:8870453] The catalytic dimer of RGGTA and B interacts with RAB-escort...
(hasEvent)	[Pathway:8873719] RAB geranylgeranylation [Homo sapiens]
(precedingEvent)	[Reaction:8870466] RGGT:CHM binds RABs [Homo sapiens]
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