Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The catalytic dimer of RGGTA and B interacts with RAB-escort...
| Class:Id | Summation:8870453 |
|---|---|
| _displayName | The catalytic dimer of RGGTA and B interacts with RAB-escort... |
| _timestamp | 2016-08-15 14:52:50 |
| created | [InstanceEdit:8870454] Rothfels, Karen, 2016-05-09 |
| modified | [InstanceEdit:8874111] Rothfels, Karen, 2016-05-20 [InstanceEdit:8876208] Rothfels, Karen, 2016-06-10 [InstanceEdit:8935805] Rothfels, Karen, 2016-08-15 |
| text | The catalytic dimer of RGGTA and B interacts with RAB-escorting proteins 1 or 2 (CHM and CHML, also known as REP-1 and REP-2) to form a functional trimeric RAB geranylgeranyl transferase complex that is capable of binding and geranylgeranylating newly synthesized RAB proteins (Baron and Seabra, 2008; reviewed in Leung et al, 2006; Gutkowska and Swiezewska, 2012). There are two models for the formation of a functional enzyme:substrate complex. In the classical model, unprenylated RAB first binds to REP and is subsequently presented to the catalytic subunits of the GGTase. Incorporation of geranylgeranyl pyrophosphate (GGPP) strengthens the interaction between enzyme and substrate (Andres et al, 1993; Thoma et al, 2001a). In the alternate route, which is depicted in this pathway, RGGTA and RGGTB first bind to REP in a GGPP-dependent manner in the absence of the RAB substrate. Unprenylated RABs then bind to the fully formed GGTase for geranylgeranylation (Thoma et al, 2001b; Baron and Seabra, 2008). |
| (summation) | [Reaction:8870465] RGGT binds the RAB-binding subunit [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The catalytic dimer of RGGTA and B interacts with RAB-escort... (8870453)
