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Details on Person UniProt:P0DN83 Strit1
| Class:Id | ReferenceGeneProduct:8869722 |
|---|---|
| _chainChangeLog | chain:1-34 added on Fri May 6 2016 |
| _displayName | UniProt:P0DN83 Strit1 |
| _timestamp | 2025-02-21 18:46:14 |
| chain | chain:1-34 |
| checksum | BC5F9BC7E8AA6F7A |
| comment | FUNCTION Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity (PubMed:26816378, PubMed:30299255). Also enhances the activity of the ATP2A2/SERCA2 ATPase (By similarity). Does not directly stimulate SERCA pump activity (PubMed:26816378). Binds preferentially to the phosphorylated E1 and E2 conformational forms of ATP2A2 which predominate at high Ca(2+) concentrations during the systolic phase of the cardiac cycle (PubMed:35605666). Competes with ATP2A2 inhibitor phospholamban (PLN) for binding to ATP2A2 and displaces PLN (By similarity). Can activate ATP2A2 directly in the absence of PLN (By similarity). Also enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN) and myoregulin (MRLN) (PubMed:26816378, PubMed:30299255).SUBUNIT Homooligomer (PubMed:31449798). Can also form heterooligomers with other sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) regulators ARLN, ERLN, PLN and SLN (By similarity). Monomer (PubMed:30299255, PubMed:31449798). Interacts with ATP2A1/SERCA1; the interaction results in activation of ATP2A1 (PubMed:26816378, PubMed:30299255). Interacts as a monomer with ATP2A2/SERCA2; the interaction results in activation of ATP2A2 (PubMed:31449798).SUBCELLULAR LOCATION Highly expressed in heart (at protein level). Detected in heart and soleus, a postural muscle group of the hindlimb containing the highest enrichment of slow-twitch muscle fibers. Also expressed in diaphragm, which contains some slow-twitch fibers. Not detected in the quadriceps, a fast-twitch muscle group, or in cardiac atrial muscle. Not expressed in the prenatal heart but gradually increases in abundance postnatally.DOMAIN The transmembrane domain is sufficient to compete with phospholamban (PLN) for binding to ATP2A2.DISRUPTION PHENOTYPE Mice produce offspring at expected Mendelian ratios. Slow-twitch skeletal muscle fibers display delayed Ca(2+) clearance and relaxation and reduced SERCA activity. No significant differences are observed in peak muscle force and no differences are observed in relaxation rates at low, non-tetanic stimulation frequencies. However at tetanus-inducing frequencies, relaxation rates are significantly slowed after tetanus. |
| created | [InstanceEdit:8869714] Weiser, JD |
| description | recommendedName: fullName evidence="8"Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF shortName evidence="8"SERCA regulator DWORF alternativeName: fullName evidence="7"Dwarf open reading frame shortName evidence="7"DWORF alternativeName: fullName evidence="9"Small transmembrane regulator of ion transport 1 |
| geneName | Strit1 |
| identifier | P0DN83 |
| isSequenceChanged | FALSE |
| keyword | Membrane Reference proteome Sarcoplasmic reticulum Transmembrane Transmembrane helix |
| modified | [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Strit1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DWORF_MOUSE |
| sequenceLength | 34 |
| species | [Species:48892] Mus musculus |
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No pathways have been reviewed or authored by UniProt:P0DN83 Strit1 (8869722)
