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Details on Person UniProt:Q9VE87 hmw
| Class:Id | ReferenceGeneProduct:8869719 |
|---|---|
| _chainChangeLog | chain:1-604 added on Fri May 6 2016 |
| _displayName | UniProt:Q9VE87 hmw |
| _timestamp | 2023-11-03 16:57:58 |
| chain | chain:1-604 |
| checksum | 27984FF0D903D364 |
| comment | FUNCTION Involved in assembly and/or maintenance of motile cilia. Required during spermatogenesis for axoneme elongation. Necessary for optimal function of the chordotonal (hearing) organs.SUBCELLULAR LOCATION Detected in ciliated sensory neurons at all stages of development, and in adult testis.DEVELOPMENTAL STAGE In the testis, expressed in spermatocytes and elongating spermatids.DISRUPTION PHENOTYPE Viable with no gross coordination or gravitaxis defects. Males are sterile with complete absence of mature spermatozoa, while female fertility is unaffected. In developing spermatids, axonemes fail to elongate normally and sperm individualization is disrupted. Tubulin glycylation of spermatid axonemes is abnormal. Hearing is moderately impaired.SIMILARITY Belongs to the CFAP97 family. |
| created | [InstanceEdit:8869714] Weiser, JD |
| description | recommendedName: fullName evidence="5"Protein hemingway |
| geneName | hmw CG7669 |
| identifier | Q9VE87 |
| isSequenceChanged | FALSE |
| keyword | Cell projection Cilium biogenesis/degradation Cytoplasm Differentiation Reference proteome Spermatogenesis |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | hmw |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | HMW_DROME Q8T0T7 |
| sequenceLength | 604 |
| species | [Species:56210] Drosophila melanogaster |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9VE87 hmw (8869719)
