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Details on Person UniProt:E9Q7P9 Cdhr2
| Class:Id | ReferenceGeneProduct:8869715 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Fri May 6 2016;chain:21-1308 added on Fri May 6 2016 |
| _displayName | UniProt:E9Q7P9 Cdhr2 |
| _timestamp | 2023-11-03 15:44:06 |
| chain | signal peptide:1-20 chain:21-1308 |
| checksum | 9C1DD3E53E556A0A |
| comment | FUNCTION Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells.SUBUNIT Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts with MAST2 (By similarity). Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR2 to microvilli tips and its function in brush border differentiation (Probable).SUBCELLULAR LOCATION The cadherin 1 domain is required for binding to CDHR5. |
| created | [InstanceEdit:8869714] Weiser, JD |
| description | recommendedName: fullName evidence="5"Cadherin-related family member 2 |
| geneName | Cdhr2 |
| identifier | E9Q7P9 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calcium Cell adhesion Cell junction Cell membrane Cell projection Differentiation Membrane Phosphoprotein Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Cdhr2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CDHR2_MOUSE B7ZP46 B9EJ32 Q3UN77 |
| sequenceLength | 1308 |
| species | [Species:48892] Mus musculus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:E9Q7P9 Cdhr2 (8869715)
