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Details on Person Cytosolic NMRK2 (nicotinamide riboside kinase 2), localized ...
| Class:Id | Summation:8869612 |
|---|---|
| _displayName | Cytosolic NMRK2 (nicotinamide riboside kinase 2), localized ... |
| _timestamp | 2025-02-10 22:29:44 |
| created | [InstanceEdit:8869619] D'Eustachio, Peter, 2016-05-05 |
| modified | [InstanceEdit:9938178] D'Eustachio, Peter, 2025-02-10 |
| text | Cytosolic NMRK2 (nicotinamide riboside kinase 2), localized predominantly in myocytes (Li et al. 1999), catalyzes the reaction of NR (N-ribosylnicotinamide) and ATP to yield NMN (beta-nicotinamide D-ribonucleotide), ADP, and H+ (Bieganowsky & Brenner 2004; Tempel et al. 2007). Covarrubias et al. (2021) suggest that extracellular NR is taken up via a specific transporter in the plasma membrane, but while proteins with this activity have been identified in prokaryotes and fungi, no homolog has been identified in mammals. |
| (summation) | [Reaction:8869627] NMRK2 phosphorylates NR to yield NMN [Homo sapiens] |
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No pathways have been reviewed or authored by Cytosolic NMRK2 (nicotinamide riboside kinase 2), localized ... (8869612)
