Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NMRK2 phosphorylates NAR to yield NAMN

Class:IdReaction:8869607
_displayNameNMRK2 phosphorylates NAR to yield NAMN
_doReleaseTRUE
_timestamp2025-02-11 17:23:34
authored[InstanceEdit:8869619] D'Eustachio, Peter, 2016-05-05
catalystActivity[CatalystActivity:8869631] nicotinate riboside kinase activity of NMRK2 [cytosol]
catalystActivityReference[CatalystActivityReference:9643566] ribosylnicotinate kinase activity of NMRK2 [cytosol] Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
compartment[Compartment:70101] cytosol
created[InstanceEdit:8869619] D'Eustachio, Peter, 2016-05-05
crossReference[DatabaseIdentifier:9937914] RHEA:25569
edited[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
input[SimpleEntity:8869365] NAR [cytosol]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9938268] D'Eustachio, Peter, 2025-02-11
isChimericFALSE
literatureReference[LiteratureReference:8869621] A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation
[LiteratureReference:8869378] Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation
[LiteratureReference:8869366] The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis
[LiteratureReference:8869349] Nicotinamide riboside kinase structures reveal new pathways to NAD+
modified[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8939814] Jassal, Bijay, 2016-09-21
[InstanceEdit:8940088] Jassal, Bijay, 2016-09-23
[InstanceEdit:8940091] Jassal, Bijay, 2016-09-23
[InstanceEdit:8942223] Jassal, Bijay, 2016-10-11
[InstanceEdit:8942352] Jassal, Bijay, 2016-10-13
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9655243] D'Eustachio, Peter, 2019-07-23
[InstanceEdit:9655301] D'Eustachio, Peter, 2019-07-24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9937906] D'Eustachio, Peter, 2025-02-07
[InstanceEdit:9938269] D'Eustachio, Peter, 2025-02-11
nameNMRK2 phosphorylates NAR to yield NAMN
beta-D-ribosylnicotinate + ATP => nicotinate beta-D-ribonucleotide + ADP + H(+)
NAR + ATP(4-) => NAMN + ADP(3-) + H+
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:8869359] NAMN [cytosol]
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2016-12-12
reviewed[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8915110] R-HSA-8869607.5
structureModified[InstanceEdit:9937906] D'Eustachio, Peter, 2025-02-07
summation[Summation:8869611] Cytosolic NMRK2 (nicotinamide riboside kinase 2), localized ...
(hasEvent)[Pathway:196807] Nicotinate metabolism [Homo sapiens]
(precedingEvent)[Reaction:197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD [Homo sapiens]
[Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD [Homo sapiens]
[Reaction:200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777523] Update Tracker - [Reaction:8869607] NMRK2 phosphorylates NAR to yield NAMN - v70:[add_removeInput, add_removeOutput]
[_UpdateTracker:9939684] Update Tracker - [Reaction:8869607] NMRK2 phosphorylates NAR to yield NAMN - v92:[add_removeOutput, modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by NMRK2 phosphorylates NAR to yield NAMN (8869607)
Follow Reactome