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Details on Person misfolded CFTR [endoplasmic reticulum membrane]

Class:Id	EntityWithAccessionedSequence:8868730
_displayName	misfolded CFTR [endoplasmic reticulum membrane]
_timestamp	2016-05-19 16:43:44
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8868729] Rothfels, Karen, 2016-04-22
endCoordinate	1480
modified	[InstanceEdit:8871616] Weiser, JD
name	misfolded CFTR Cystic fibrosis transmembrane conductance regulator CFTR_HUMAN
referenceEntity	[ReferenceGeneProduct:51930] UniProt:P13569 CFTR [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8872689] R-HSA-8868730.2
startCoordinate	1
(hasComponent)	[Complex:8866534] Ub-misfolded nascent CFTR [cytosol] [Homo sapiens] [Complex:8866538] misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] [Homo sapiens] [Complex:9659983] Ub-misfolded nascent CFTR [late endosome lumen] [Homo sapiens] [Complex:9660030] Ub-misfolded nascent CFTR [lysosomal lumen] [Homo sapiens] [Complex:9665106] PolyUb-misfolded nascent CFTR [cytosol] [Homo sapiens]
(input)	[Reaction:8866551] CFTR binds components of the ERAD machinery for ubiquitination and degradation [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:9630127] gain_of_function of CFTR F508del [endoplasmic reticulum membrane]
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No pathways have been reviewed or authored by misfolded CFTR [endoplasmic reticulum membrane] (8868730)