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Details on Person Endophilins recruit synaptojanins to the clathrin-coated pit
Class:Id Reaction:8868651 _displayName Endophilins recruit synaptojanins to the clathrin-coated pit _doRelease TRUE _timestamp 2016-05-19 16:46:06 authored [InstanceEdit:8870660] Rothfels, Karen, 2016-05-10 compartment [Compartment:876] plasma membrane created [InstanceEdit:8868650] Rothfels, Karen, 2016-04-22 edited [InstanceEdit:8870660] Rothfels, Karen, 2016-05-10 input [Complex:8868234] PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] [Homo sapiens] [DefinedSet:1806173] SYNJs,OCRL [cytosol] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:8868467] Essential role of phosphoinositide metabolism in synaptic vesicle recycling [LiteratureReference:8868475] Inositol lipid phosphatases in membrane trafficking and human disease [LiteratureReference:1675977] Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15 [LiteratureReference:8868539] The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity [LiteratureReference:8868452] Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth [LiteratureReference:8868456] Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin [LiteratureReference:8868529] Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating [LiteratureReference:8868439] All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis [LiteratureReference:8868547] Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages [LiteratureReference:8868492] Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission [LiteratureReference:8868479] Molecular circuitry of endocytosis at nerve terminals [LiteratureReference:8868162] A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis [LiteratureReference:8868489] Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size [LiteratureReference:8868519] Synaptojanin 1-mediated PI(4,5)P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission [LiteratureReference:8867983] BAR domain scaffolds in dynamin-mediated membrane fission [LiteratureReference:8856473] Molecular mechanism and physiological functions of clathrin-mediated endocytosis [LiteratureReference:8871052] A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway [LiteratureReference:8871037] A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism [LiteratureReference:8871050] A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells modified [InstanceEdit:8870643] Rothfels, Karen, 2016-05-10 [InstanceEdit:8870663] Rothfels, Karen, 2016-05-10 [InstanceEdit:8871208] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Endophilins recruit synaptojanins to the clathrin-coated pit output [Complex:8868634] PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] [Homo sapiens] precedingEvent
releaseDate 2016-06-15 reviewed [InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:8873349] R-HSA-8868651.3 summation [Summation:8868549] Synaptojanin (SYNJ) 1 and 2 are inositol-5-phosphatases that... (hasEvent) [Pathway:8856828] Clathrin-mediated endocytosis [Homo sapiens] (precedingEvent) [Reaction:8868648] SYNJ hydrolyze PI(4,5)P2 to PI(4)P [Homo sapiens]
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No pathways have been reviewed or authored by Endophilins recruit synaptojanins to the clathrin-coated pit (8868651)
