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Details on Person Oxysterol-binding protein 1 (OSBP) is involved in lipid coun...
| Class:Id | Summation:8868390 |
|---|---|
| _displayName | Oxysterol-binding protein 1 (OSBP) is involved in lipid coun... |
| _timestamp | 2016-04-21 12:09:35 |
| created | [InstanceEdit:8868394] Jassal, Bijay, 2016-04-21 |
| text | Oxysterol-binding protein 1 (OSBP) is involved in lipid countertransport between the Golgi and the ER membranes. It specifically exchanges sterols such as 25-hydroxycholesterol (25OH-CHOL) with phosphatidylinositol 4-phosphate (PI4P), delivering it to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatases in the ER. The PH-FFAT region of OSBP is necessary for membrane tethering, which then directs forward sterol and backward PI4P transport by the ORD domain of OSBP (Mesmin et al. 2013). |
| (summation) | [Reaction:8868402] OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane [Homo sapiens] |
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No pathways have been reviewed or authored by Oxysterol-binding protein 1 (OSBP) is involved in lipid coun... (8868390)
