Query author contributions in Reactome
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Details on Person Alzheimer's disease (AD), like many other neurodegenerative ...
| Class:Id | Summation:8868373 |
|---|---|
| _displayName | Alzheimer's disease (AD), like many other neurodegenerative ... |
| _timestamp | 2016-04-22 18:44:08 |
| created | [InstanceEdit:8868372] Orlic-Milacic, Marija, 2016-04-20 |
| literatureReference | [LiteratureReference:8868146] Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death |
| modified | [InstanceEdit:8868387] Orlic-Milacic, Marija, 2016-04-20 [InstanceEdit:8868679] Orlic-Milacic, Marija, 2016-04-22 [InstanceEdit:8868681] Orlic-Milacic, Marija, 2016-04-22 |
| text | Alzheimer's disease (AD), like many other neurodegenerative diseases, is characterized by nuclear envelope fragmentation. Based on a mouse AD model, nuclear fragmentation is initiated by phosphorylation of nuclear lamins by p25-activated CDK5. The CDK5:p25 complex phosphorylates lamin B1 (LMNB1) at serine residues S23 and S393. Nuclear envelope fragmentation increases access of the CDK5:p25 complex to nuclear proteins and precedes neuronal death (Chang et al. 2011). |
| (summation) | [Reaction:8868340] CDK5:p25 phosphorylates lamin B1 [Homo sapiens] |
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No pathways have been reviewed or authored by Alzheimer's disease (AD), like many other neurodegenerative ... (8868373)
