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Details on Person Golgi fragmentation is observed in neurodegenerative disease...
| Class:Id | Summation:8868335 |
|---|---|
| _displayName | Golgi fragmentation is observed in neurodegenerative disease... |
| _timestamp | 2016-04-22 18:44:08 |
| created | [InstanceEdit:8868334] Orlic-Milacic, Marija, 2016-04-20 |
| literatureReference | [LiteratureReference:8868261] Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease [LiteratureReference:2245207] Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis |
| modified | [InstanceEdit:8868339] Orlic-Milacic, Marija, 2016-04-20 [InstanceEdit:8868681] Orlic-Milacic, Marija, 2016-04-22 |
| text | Golgi fragmentation is observed in neurodegenerative diseases, including Alzheimer's disease. The underlying mechanism, based on a mouse AD model, is the phosphorylation of the Golgi membrane protein GOLGA2 (GM130) by the CDK5:p25 complex. CDK5:p25 phosphorylates GOLGA2 (GM130) on a conserved residue S37, phosphorylated by CDK1 in mitotic prophase (Lowe et al. 1998), triggering Golgi apparatus disassembly in Alzheimer's disease (Sun et al. 2008). Please note that S37 of GOLGA2 is sometimes labeled as S25 in the literature because the recombinant Golga2 construct used in the original study of mitotic Golgi fragmentation (Lowe et al. 1998) lacked 12 N-terminal amino acids of Golga2. |
| (summation) | [Reaction:8868260] CDK5:p25 phosphorylates GOLGA2 [Homo sapiens] |
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No pathways have been reviewed or authored by Golgi fragmentation is observed in neurodegenerative disease... (8868335)
